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Bacterial Biomarkers: New Aspects of Colorectal Tumors Diagnosis: Reality or Fantasy Publisher Pubmed



Shahbazi T1 ; Bakhshi B1 ; Sadegh Fazeli M2 ; Derakhshannezhadc E3
Authors
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Authors Affiliations
  1. 1. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Iran
  2. 2. Department of Surgery, Division of Colo-Rectal Surgery, Imam Khomeini Medical Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: European Journal of Cancer Prevention Published:2023


Abstract

As one of the most common cancers, colorectal cancer (CRC) is considered as a significant leading cause of cancer-related deaths worldwide. Gut microbiota is part of a complex microbial-based ecosystem in the human body so that changes in the microbiota could lead to a variety of diseases. A growing number of studies have shown that bacteria are both individually and collectively involved in the progression of CRC. The present review study provided a summary of some of the available data on the advantages and limitations of current CRC screening methods as well as gut biomarkers including genetic, epigenetic, and protein markers. Moreover, a summary of the applications and limitations in the detection of gut microbiota markers as well as their role in early diagnosis and timely treatment response in CRC patients was provided. © 2023 Lippincott Williams and Wilkins. All rights reserved.
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