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An Update on Treatment Options for Primary Sclerosing Cholangitis Publisher



Iravani S1, 2 ; Dooghaiemoghadam A3 ; Razavikhorasani N3 ; Moazzami B3 ; Beirami AD4 ; Mansourghanaei A4 ; Majidzadeha K1 ; Mehrvar A1 ; Khoshdel A1 ; Toosi MN3 ; Sadeghi A4
Authors
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Authors Affiliations
  1. 1. Research Center for Cancer Screening and Epidemiology, AJA University of Medical Sciences, Tehran, Iran
  2. 2. Gastroenterology and Hepatobiliary Research Center, AJA University of Medical Sciences, Tehran, Iran
  3. 3. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Department of Liver Transplantation, Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2020


Abstract

Primary sclerosing cholangitis is a chronic cholestatic liver disease defined by strictures of the biliary tree which could ultimately lead to liver cirrhosis and cholangiocarcinoma. Although the exact underlying etiology of this disorder is not fully understood, the pathology is believed to be caused by immune mediated mechanisms. Growing body of evidence suggests several treatment modalities mainly focusing on the inflammation aspect of this disorder. However, there is still no consensus regarding the best treatment option for these patients. Thus, the present study aimed to review the current treatment options for patients with primary sclerosing cholangitis. © 2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.