Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Potential of 5-Aminolevulinic Acid As a Contrast Agent in Mr Imaging: Challenges and Opportunities Publisher



Ebrahimpour A1 ; Alam NR1 ; Khoobi M2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center (MBRC), Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Sciences# Islamic Republic of Iran Published:2021


Abstract

Nowadays, 5-aminolevulinic acid (5-ALA) plays an influential role in the detection of malignant tumors as a photodynamic diagnosis tool. Nevertheless, an outlook regarding 5-ALA applicability in magnetic resonance imaging (MRI) has recently emerged. Many studies confirmed the impact of 5-ALA on promoting intracellular Heme synthesis and iron metabolism, which support the capability of 5-ALA in MRI owing to the susceptibility effect of iron. Therefore, concerning the high safety and high affinity of 5-ALA to tumor cells, 5-ALA-based MRI could be an intriguing method for malignant foci identification. © 2021 National Research Center of Medical Sciences. All rights reserved.
Related Docs
1. Detection of Glioblastoma Multiforme Using Quantitative Molecular Magnetic Resonance Imaging Based on 5-Aminolevulinic Acid: In Vitro and in Vivo Studies, Magnetic Resonance Materials in Physics# Biology and Medicine (2022)
2. Reliable Differentiation of Necrosis and Active Metabolically Contours of Glioblastoma Multiforme Using Susceptibility-Based Imaging, Heliyon (2024)
3. Ph-Responsive Chitosan-Modified Gadolinium Oxide Nanoparticles Delivering 5-Aminolevulinic Acid: A Dual Cellular and Metabolic T1-T2* Contrast Agent for Glioblastoma Brain Tumors Detection, Journal of Molecular Liquids (2022)
4. A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies, Carbohydrate Polymers (2021)
5. Enhancing 5-Ala-Pdt Efficacy Against Resistant Tumor Cells: Strategies and Advances, Life Sciences (2024)
6. Iron Quantification in Basal Ganglia: Quantitative Susceptibility Mapping As a Potential Biomarker for Alzheimer’S Disease – a Systematic Review and Meta-Analysis, Frontiers in Neuroscience (2024)
7. Lymph Node Metastases Detection Using Gd2o3@Pcd As Novel Multifunctional Contrast Imaging Agent in Metabolic Magnetic Resonance Molecular Imaging, Contrast Media and Molecular Imaging (2022)
8. Multifunctional Gold Helix Phototheranostic Biohybrid That Enables Targeted Image-Guided Photothermal Therapy in Breast Cancer, ACS Applied Materials and Interfaces (2022)
Experts (# of related papers)
View all Related Experts
Mehdi Khoobi (6)
Anita Ebrahimpour (5)