Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions

Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions

Niyyati M¹ ; Sasani R² ; Mohebali M² ; Ghazikhansari M³ ; Kargar F⁴ ; Hajialilo E² ; Rezaeian M²

Show Affiliations

1. Dept. of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Dept. of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Dept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Parasitology Published:2018

Abstract

Background: This study aimed to investigate the anti-Acanthamoeba effects of the most used marketed disinfecting solutions in Iran. Moreover, the efficacy of some nano-compounds was tested against pathogenic Acanthamoeba. Methods: The present study was conducted in the School of Public Health, Tehran University of Medical sciences, Tehran, Iran during 2015-2016. Cysts of Acanthamoeba T4 genotype (7 x 104/ml) mixed at the equal volume with contact lens solutions including Opti-free, Ginza, ReNu, Maxima, Light, and Cyclean for the recommended time by the manufacturers. Nano-silver and nano-gold compounds were also treated with the amoebae. Chlorhexidine 0.02% and normal saline were used as positive and negative controls, respectively. Dead and alive amoebae were determined using vital stain and suspension was cultured in non-nutrient agar. The entire process was repeated at least three times. Results: In none of the solutions in the manufacturer's brochure recommended time, full cytotoxic effect was observed on the cysts of Acanthamoeba. Opti free express solution destroyed the cysts after 6 days. Nanosilver and nano-gold compounds showed no cytotoxic effect on the cysts of Acanthamoeba. Conclusion: None of the Nanoparticles compounds as well as contact lenses disinfecting solutions which studied was effective on Acanthamoeba cysts in the manufacturer's brochure recommended time. However, continuing study on Nano-silver and Nano-gold compounds to find effective ingredients against Acanthamoeba are highly recommended. © 2018, Tehran University of Medical Sciences (TUMS). All rights reserved.

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Mahdi Mohebali (2)

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Style	Citing Format
MLA	Niyyati M, et al.. "Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions." Iranian Journal of Parasitology, vol. 13, no. 2, 2018, pp. 180-185.
APA	Niyyati M, Sasani R, Mohebali M, Ghazikhansari M, Kargar F, Hajialilo E, Rezaeian M (2018). Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions. Iranian Journal of Parasitology, 13(2), 180-185.
Chicago	Niyyati M, Sasani R, Mohebali M, Ghazikhansari M, Kargar F, Hajialilo E, Rezaeian M. "Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions." Iranian Journal of Parasitology 13, no. 2 (2018): 180-185.
Harvard	Niyyati M et al. (2018) 'Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions', Iranian Journal of Parasitology, 13(2), pp. 180-185.
Vancouver	Niyyati M, Sasani R, Mohebali M, Ghazikhansari M, Kargar F, Hajialilo E, et al.. Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions. Iranian Journal of Parasitology. 2018;13(2):180-185.
BibTex	@article{ author = {Niyyati M and Sasani R and Mohebali M and Ghazikhansari M and Kargar F and Hajialilo E and Rezaeian M}, title = {Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions}, journal = {Iranian Journal of Parasitology}, volume = {13}, number = {2}, pages = {180-185}, year = {2018} }
RIS	TY - JOUR AU - Niyyati M AU - Sasani R AU - Mohebali M AU - Ghazikhansari M AU - Kargar F AU - Hajialilo E AU - Rezaeian M TI - Anti-Acanthamoeba Effects of Silver and Gold Nanoparticles and Contact Lenses Disinfection Solutions JO - Iranian Journal of Parasitology VL - 13 IS - 2 SP - 180 EP - 185 PY - 2018 ER -

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