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Patient-Specific Study of Post-Ischemic Cardiac Ventricular Remodeling: A Passive Simulation of Structural Changes in Myofiber Orientation and Stiffness Publisher



Torbati S1 ; Heidari A2 ; Daneshmehr A3 ; Pouraliakbar H4 ; Tafti SHA5 ; Shumtim D6
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. McGill University, Department of Mechanical Engineering, Department of Anatomy & Cell Biology, Montreal, QC, Canada
  3. 3. School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  4. 4. Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Tehran Heart Center, Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran University of Medical Sciences, Department of Surgery, Tehran, Iran
  6. 6. McGill University, Division of Cardiac Surgery, Department of Surgery, Montreal, QC, Canada

Source: 2022 29th National and 7th International Iranian Conference on Biomedical Engineering# ICBME 2022 Published:2022


Abstract

Despite recent advances in the computational modeling of cardiovascular diseases and therapies, the effect of post-ischemic remodeling has not been thoroughly studied while considering the unloaded ventricles. Further evaluation is, therefore, needed in order to better understand the effect of alterations in myocardial structure. Herein, we have developed a patient-specific computational model of ischemic cardiomyopathy to assess the influence of microstructure and material change on passive ventricular mechanics. The biventricular geometry has been built and unloaded based on cardiac magnetic resonance (CMR) images of a 64-year-old male patient at end-diastole (ED). Different fiber orientations and material scales were assumed for the model. Results indicated that although some fiber structures produce similar end-diastolic pressure-volume relationships (EDPVRs), differences in initial stress-free shapes and strain patterns determine the subsequent damage to the myocardium. Moreover, stiffening the healthy region means lower myofiber strain. However, material change in the ischemic areas of the ventricles does not alter the passive fiber strain considerably. Such evaluations are required when choosing optimal therapies to alleviate the adverse effects of ischemic cardiomyopathy. © 2022 IEEE.
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