Canine Inflammatory Mammary Carcinoma As a Promising Model for Cancer Pathology and Anticancer Drug Development: Lessons From a Case Series Publisher



Rismanchi S¹ ; Mortazavi P¹ ; Muhammadnejad S² Show Affiliations
Source: Turk Onkoloji Dergisi Published:2021

Abstract

OBJECTIVE The prognosis of Inflammatory Breast Carcinoma (IBC) in women is weaker than other types of breast cancer. Inflammatory Mammary Carcinoma (IMC) is a spontaneous breast malignancy in dog which, according to some scientific evidence, can be a good model for women’s IBC studies. This study aimed to describe the clinical, pathological, immunohistochemistry characteristics and clinical findings of relapse in IMC compared with IBC. METHODS This study was a case series, and 10 dogs confirmed for IMC diagnosis were included. Their clinical and pathological parameters and recurrence findings and Disease-Free Survival Rate (DFS) were calculated, and paraffinic blocks were stained by ER, PR, HER2, Ki67, TP53 and COX2 markers and their relationships with DFS was obtained. RESULTS In 40% of cases the lymph nodes were involved. All tumors were high-grade and had 70% of vascular invasion and dirty margins. Evaluation with IHC showed only 10% of them were hormone receptor positive and 70% were HER2 positive. Ki67 was high in all patients and HER2 and triple negatives molecular subtypes accounted for 70% and 30% of cases, respectively. 80% of cases were p53, and the COX2 enzyme was positive in all cancers. Statistical analysis showed that DFS was associated with Ki67 expression and the risk of recurrence increased with the elevation of its expression. CONCLUSION In dogs, IMC mimics many of the clinical, pathological, and molecular characteristics of human IBC, and is likely to be a suitable model for comparative oncology studies. © 2021, Turkish Society for Radiation Oncology.