Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone

Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone Publisher Pubmed

Nakhjavani M¹ ; Amirbaigloo A² ; Rabizadeh S¹ ; Rotondo F^{3, 4} ; Kovacs K^{3, 4} ; Ghazi AA⁵

Show Affiliations

1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Endocrinologist, Practicing in Private Office, Karaj, Iran
3. Department of Laboratory Medicine, Division of Pathology, Toronto, Canada
4. The Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St. Michaelâ€™s Hospital, University of Toronto, Toronto, ON, Canada
5. Endocrine Research Center, Research Institute for Endocrine Sciences (RIES), Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, Iran

Source: Pituitary Published:2019

Abstract

Abstract: Cushing’s syndrome (CS) secondary to corticotropin releasing hormone (CRH) producing tumors is rare. In this paper we present an Iranian patient who was admitted to our hospital with classic signs and symptoms of CS. Laboratory evaluation revealed high serum and urine cortisol which could not be suppressed with dexamethasone. Abdominal CT scan revealed a mass in abdominal cavity. A percutaneous needle biopsy was performed and histopathologic evaluation revealed that the mass was a neuroendocrine tumor. A multi-disciplinary approach including resection of the mass, bilateral adrenalectomy somatostatin analogue and chemotherapy was applied for management of the disease. Extensive review of English literature focusing on the topic from 1971 to 2018 revealed that there have been only 75 similar cases. Clinical, laboratory, imaging, histopathologic characteristics and managements of these patients will also be discussed in this paper. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Style	Citing Format
MLA	Nakhjavani M, et al.. "Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone." Pituitary, vol. 22, no. 5, 2019, pp. 561-568.
APA	Nakhjavani M, Amirbaigloo A, Rabizadeh S, Rotondo F, Kovacs K, Ghazi AA (2019). Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone. Pituitary, 22(5), 561-568.
Chicago	Nakhjavani M, Amirbaigloo A, Rabizadeh S, Rotondo F, Kovacs K, Ghazi AA. "Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone." Pituitary 22, no. 5 (2019): 561-568.
Harvard	Nakhjavani M et al. (2019) 'Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone', Pituitary, 22(5), pp. 561-568.
Vancouver	Nakhjavani M, Amirbaigloo A, Rabizadeh S, Rotondo F, Kovacs K, Ghazi AA. Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone. Pituitary. 2019;22(5):561-568.
BibTex	@article{ author = {Nakhjavani M and Amirbaigloo A and Rabizadeh S and Rotondo F and Kovacs K and Ghazi AA}, title = {Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone}, journal = {Pituitary}, volume = {22}, number = {5}, pages = {561-568}, year = {2019} }
RIS	TY - JOUR AU - Nakhjavani M AU - Amirbaigloo A AU - Rabizadeh S AU - Rotondo F AU - Kovacs K AU - Ghazi AA TI - Ectopic Cushing’S Syndrome Due to Corticotropin Releasing Hormone JO - Pituitary VL - 22 IS - 5 SP - 561 EP - 568 PY - 2019 ER -

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Abstract