Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors

Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors Publisher Pubmed

Behfar M¹ ; Faghihikashani S¹ ; Hosseini AS¹ ; Ghavamzadeh A¹ ; Hamidieh AA²

Show Affiliations

1. Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Children's Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

Source: Biology of Blood and Marrow Transplantation Published:2018

Abstract

Administration of filgrastim (recombinant human granulocyte colony-stimulating factor [rhG-CSF]) (Neupogen) in healthy donors to mobilize hematopoietic stem cells (HSCs) is a widespread practice in adults. Application of peripheral blood stem cell (PBSC) collection in normal pediatric donors is scarce due to ethical issues. Hence, there are insufficient data on the long-term impact of PBSC procedure in healthy children. This retrospective study aimed to evaluate the early and late adverse effects of PBSC donation in pediatric donors. Bone marrow and PBSC procedures and known adverse events of each technique were completely explained to parents and when applicable to children and written informed consent was obtained. rhG-CSF was administered for 4 days. HSCs were collected on the fifth day through continuous-flow apheresis and donors were followed for 30 days. Manual chart review was performed to collect short-term complications. Donors’ health status was assessed via a questionnaire. A total of 145 healthy pediatric donors with a median age of 10 years at the time of donation (2 to 15 years) were followed for a median of 4.8 years (range, 1.2 to 14.2 years). The most frequent symptoms of rhG-CSF administration were fatigue (5%) and headache (3%). Thirty-five (24%) donors experienced hypocalcaemia during apheresis procedure that quickly responded to treatment. Two pregnancies occurred after rhG-CSF administration that resulted in normal births. We did not encounter any serious adverse events, including neoplastic disorders and death in this study. rhG-CSF and leukophresis procedure were well-tolerated in this study and all children completed the donation process without interruption or reduction of rhG-CSF dosage. Our results suggest that rhG-CSF is a safe drug in healthy children for the purpose of HSC mobilization. © 2017 The American Society for Blood and Marrow Transplantation

Style	Citing Format
MLA	Behfar M, et al.. "Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors." Biology of Blood and Marrow Transplantation, vol. 24, no. 4, 2018, pp. 866-870.
APA	Behfar M, Faghihikashani S, Hosseini AS, Ghavamzadeh A, Hamidieh AA (2018). Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors. Biology of Blood and Marrow Transplantation, 24(4), 866-870.
Chicago	Behfar M, Faghihikashani S, Hosseini AS, Ghavamzadeh A, Hamidieh AA. "Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors." Biology of Blood and Marrow Transplantation 24, no. 4 (2018): 866-870.
Harvard	Behfar M et al. (2018) 'Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors', Biology of Blood and Marrow Transplantation, 24(4), pp. 866-870.
Vancouver	Behfar M, Faghihikashani S, Hosseini AS, Ghavamzadeh A, Hamidieh AA. Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors. Biology of Blood and Marrow Transplantation. 2018;24(4):866-870.
BibTex	@article{ author = {Behfar M and Faghihikashani S and Hosseini AS and Ghavamzadeh A and Hamidieh AA}, title = {Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors}, journal = {Biology of Blood and Marrow Transplantation}, volume = {24}, number = {4}, pages = {866-870}, year = {2018} }
RIS	TY - JOUR AU - Behfar M AU - Faghihikashani S AU - Hosseini AS AU - Ghavamzadeh A AU - Hamidieh AA TI - Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors JO - Biology of Blood and Marrow Transplantation VL - 24 IS - 4 SP - 866 EP - 870 PY - 2018 ER -

Style

Citing Format

MLA

Behfar M, et al.. "Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors." Biology of Blood and Marrow Transplantation, vol. 24, no. 4, 2018, pp. 866-870.

APA

Behfar M, Faghihikashani S, Hosseini AS, Ghavamzadeh A, Hamidieh AA (2018). Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors. Biology of Blood and Marrow Transplantation, 24(4), 866-870.

Chicago

Behfar M, Faghihikashani S, Hosseini AS, Ghavamzadeh A, Hamidieh AA. "Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors." Biology of Blood and Marrow Transplantation 24, no. 4 (2018): 866-870.

Harvard

Behfar M et al. (2018) 'Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors', Biology of Blood and Marrow Transplantation, 24(4), pp. 866-870.

Vancouver

Behfar M, Faghihikashani S, Hosseini AS, Ghavamzadeh A, Hamidieh AA. Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors. Biology of Blood and Marrow Transplantation. 2018;24(4):866-870.

BibTex

@article{ author = {Behfar M and Faghihikashani S and Hosseini AS and Ghavamzadeh A and Hamidieh AA}, title = {Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors}, journal = {Biology of Blood and Marrow Transplantation}, volume = {24}, number = {4}, pages = {866-870}, year = {2018} }

RIS

TY - JOUR
AU - Behfar M
AU - Faghihikashani S
AU - Hosseini AS
AU - Ghavamzadeh A
AU - Hamidieh AA
TI - Long-Term Safety of Short-Term Administration of Filgrastim (Rhg-Csf) and Leukophresis Procedure in Healthy Children: Application of Peripheral Blood Stem Cell Collection in Pediatric Donors
JO - Biology of Blood and Marrow Transplantation
VL - 24
IS - 4
SP - 866
EP - 870
PY - 2018
ER -

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