Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis

Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis Publisher Pubmed

Heshmati ZS ; Amiriyekta A ; Khosravifar M ; Akbarian F ; Moini A ; Eftekhariyazdi P ; Hafezi M ; Afsharian P

Source: Scientific Reports Published:2026

Abstract

Endometriosis is a chronic, multifactorial disorder. Reactive oxygen species (ROS) and oxidative stress (OS) contribute to the development of endometriosis by affecting apoptosis-related genes in granulosa cells. N-acetylcysteine (NAC) is an antioxidant that reduces OS. This randomized controlled trial aimed to investigate the effects of NAC on serum levels of superoxide dismutase (SOD) and total antioxidant capacity (TAC), as well as the expression of apoptotic genes in granulosa cells. Infertile women with endometriosis were enrolled and administered either NAC (1200 mg/day; n = 11) or placebo (n = 14). Enzyme-linked immunosorbent assay (ELISA) was used to measure serum SOD and TAC levels. The expression of Bcl-2, Bax, and Caspase-3 genes in granulosa cells was evaluated by Real-Time Polymerase Chain Reaction. NAC treatment increased serum SOD and TAC levels. Additionally, the expression of pro-apoptotic genes Bax and Caspase-3 in granulosa cells decreased compared to the placebo group, while the expression of the anti-apoptotic gene Bcl-2 increased. We conclude that administration of N-acetylcysteine (NAC) can reduce apoptosis in granulosa cells of women with infertility due to endometriosis. © The Author(s) 2025.

Style	Citing Format
MLA	Heshmati ZS, et al.. "Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis." Scientific Reports, vol. 16, no. 1, 2026, pp. -.
APA	Heshmati ZS, Amiriyekta A, Khosravifar M, Akbarian F, Moini A, Eftekhariyazdi P, Hafezi M, Afsharian P (2026). Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis. Scientific Reports, 16(1), -.
Chicago	Heshmati ZS, Amiriyekta A, Khosravifar M, Akbarian F, Moini A, Eftekhariyazdi P, Hafezi M, Afsharian P. "Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis." Scientific Reports 16, no. 1 (2026): -.
Harvard	Heshmati ZS et al. (2026) 'Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis', Scientific Reports, 16(1), pp. -.
Vancouver	Heshmati ZS, Amiriyekta A, Khosravifar M, Akbarian F, Moini A, Eftekhariyazdi P, et al.. Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis. Scientific Reports. 2026;16(1):-.
BibTex	@article{ author = {Heshmati ZS and Amiriyekta A and Khosravifar M and Akbarian F and Moini A and Eftekhariyazdi P and Hafezi M and Afsharian P}, title = {Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis}, journal = {Scientific Reports}, volume = {16}, number = {1}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Heshmati ZS AU - Amiriyekta A AU - Khosravifar M AU - Akbarian F AU - Moini A AU - Eftekhariyazdi P AU - Hafezi M AU - Afsharian P TI - Administration of N-Acetylcysteine Influence the Expression of Apoptotic Genes in the Granulosa Cells of Infertile Women Diagnosed With Endometriosis JO - Scientific Reports VL - 16 IS - 1 SP - EP - PY - 2026 ER -

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