Evaluation the Efficacy of Trichloroacetic Acid (Tca) 33% in Treatment of Oral Retinoid-Induced Cheilitis Compared With Placebo (Vaseline): A Randomized Pilot Study Publisher Pubmed



Mansouri P¹ ; Azizian Z¹ ; Hejazi S¹ ; Chalangari R² ; Chalangari KM²
Source: Journal of Dermatological Treatment Published:2018

Abstract

Background: Oral Isotretinoin (13-cis-retinoic acid) is a gold standardtreatment for severe forms of acne with cheilitis as a most frequent complication. We designed this novel study to investigate the therapeutic effect of trichloroacetic acid (TCA) 33% as compared with placebo to treat cheilitis. Methods: In this pilot study, 90 acne vulgaris patients between 18 and 50 years, who referred dermatologic clinic with cheilitis, were assigned to either case (TCA) or control (Vaseline) group using permuted-block randomization from 2013 to 2015 with data analysis in 2016. Patients had follow-up visits after 2 and 6 weeks, at which their lesions were photographed. Two blinded expert dermatologists recorded physician International global score for each image. Results: Ninety eligible patients were randomly allocated into two groups. This included 45 patients in each group. At the end of follow-up, 44 patients in the intervention group and 37 patients in control group completed the final assessment. Compared to the control group, the TCA group had a greater reduction in the mean ICGS value from baseline to Week 6 (mean difference 2.59 points, p <.0001). Conclusions: TCA can be considered as a good strategy in improvement of cheilitis to isotretinoin therapy. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.