Oral Metagenomics Changes the Game in Carcinogenesis Publisher



My Marzbali Mahsa YOUSEFPOUR ; M Banakar MORTEZA ; Sm Mousavi Seyyed MOJTABA ; Cw Lai Chin WEI
Source: Published:2024

Abstract

Conversely, oral health has a crucial role in general health. So, diverse microbiomes in the oral cavity help in the early identification of other health problems, and their changes demonstrate a potential for pathogenesis. Oral microbiota and periodontal diseases are associated with many acute and chronic diseases, such as cancer. Microbiomes mediate carcinogenesis by different mechanisms, such as chronic inflammation, inhibition of cellular apoptosis by activation of NF-B, and bacterial products that act in a carcinogenic manner. Nowadays, metagenomics has revealed a new approach to introducing microbiome signatures at the molecular level. Thus oral metagenomics has proven an accurate method for detecting the pathogenesis of oral microbiota in malignancies and other microbe-associated diseases. Dentistry sewage and saliva mixed with water waste in the dental unit could be screened for personalized bacteria for cancer treatment. This chapter aims to represent the importance of oral microbiota and how metagenomics has been applied to improve carcinogenesis studies. © 2024 Elsevier B.V., All rights reserved.