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Repetitive Transcranial Magnetic Stimulation Improved Symptoms of Obsessive-Compulsive Disorders But Not Executive Functions: Results From a Randomized Clinical Trial With Crossover Design and Sham Condition Publisher Pubmed



Shayganfard M1 ; Jahangard L1 ; Nazaribadie M1 ; Haghighi M1 ; Ahmadpanah M1 ; Bahmani DS3 ; Bajoghli H2 ; Holsboertrachsler E3 ; Brand S3, 4
Authors
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Authors Affiliations
  1. 1. Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Center for Affective, Stress, and Sleep Disorders, University of Basel, Psychiatric Clinics (UPK), Wilhelm Klein-Strasse 27, Basel, CH-4027, Switzerland
  4. 4. Division of Sport Science and Psychosocial Health, Department of Sport, Exercise, and Health, University of Basel, Basel, Switzerland

Source: Neuropsychobiology Published:2017


Abstract

Objective: Whereas there is growing evidence that repetitive transcranial magnetic stimulation (rTMS) favorably impacts on symptoms of obsessive-compulsive disorders (OCD), less is known regarding the influence of rTMS on cognitive performance of patients with OCD. Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and executive functions in such patients. Methods: We assessed 10 patients diagnosed with OCD (mean age: 33.5 years) and treated with a standard medication; they were randomly assigned either to a treatment-first or to a sham-first condition. Symptom severity (experts' ratings) and executive functions (Wisconsin Card Sorting Test) were assessed by independent raters unaware of the patients' group assignments at baseline, after 2 and 4 weeks. After 2 weeks, treatment switched to sham condition, and sham condition switched to treatment condition. Results: Under treatment but not under sham conditions, symptom severity decreased. Performance on the executive function test increased continuously with every new assessment and was unrelated to rTMS treatment. Conclusion: Whereas the present study confirmed previous research suggesting that rTMS improved symptoms of OCD, rTMS did not improve executive functions to a greater degree than sham treatment. More research is needed to investigate the effect of rTMS on executive functions in patients with OCD. © 2017 S. Karger AG, Basel. Copyright: All rights reserved.
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