Mthfr and Apoe Genetic Variants Association With Sudden Sensorineural Hearing Loss Publisher Pubmed



Hamidi AK¹ ; Yazdani N² ; Seyedjavadi KH³ ; Ahrabi NZ³ ; Tajdini A² ; Aghazadeh K² ; Amoli MM² Show Affiliations
Source: American Journal of Otolaryngology - Head and Neck Medicine and Surgery Published:2019

Abstract

Hypothesis: Although the pathogenesis of sudden sensorineural hearing loss (SSNHL) is not clear, however several causes including genetic factors seems to be implicated. We hypothesized that common genetic variants might be involved in SSNHL. Background: SSNHL is known to be an idiopathic disease because the causative factors have not been identified. Several causes including genetic and viral infection besides immune system reaction, neurological disorders, medications, etc. have been previously reported. We examined the association between ApoE and MTHFR gene variants in SSNHL. Methods: This study includes case-control scheme encompassing a total of 177 individuals, include patients inflicted with SSNHL and healthy subjects as control group. Genotyping of MTHFR and ApoE variants was conducted by PCR – RFLP method. Result: Our study showed that MTHFR rs1801133 allele frequency is significantly different between cases and controls. Also genotype distribution of ApoE was significantly different between patients and healthy controls. Conclusions: MTHFR C677T and ApoE gene variant may be associated with sudden sensorineural hearing loss in an Iranian population. © 2018 Elsevier Inc.