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Unexpected Recurrence and Rapid Progression of Lacrimal Gland Adenoid Cystic Carcinoma During Pregnancy: A Case Report Publisher Pubmed



Rafizadeh SM1 ; Ghadimi H2 ; Zarei Vesal N1 ; Nozarian Z1 ; Nikdel M2
Authors
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Authors Affiliations
  1. 1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Ophthalmology, Private practice, Rasht, Iran

Source: Orbit (London) Published:2023


Abstract

Adenoid cystic carcinoma (ACC) is the most common malignant neoplasm involving the lacrimal glands, with high rates of recurrence and metastasis. During the pregnancy, reports of recurrence of ACC of the salivary glands and trachea have previously been published, but no lacrimal gland ACC recurrence has been reported. We present a 35-year-old woman with lacrimal gland ACC who was initially treated by surgical resection and adjunctive radiotherapy, but her cancer recurred during pregnancy, with rapid progression to cavernous sinuses and brain. Estrogen and progesterone receptors have been detected on lacrimal glands and ACCs of salivary glands. Thus, hormonal changes during pregnancy might contribute to the recurrence of ACC. However, the inherent invasive and recurrent nature of ACC could also account for the regrowth in this patient and further molecular studies can provide more accurate explanations. © 2022 Taylor & Francis Group, LLC.