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Spontaneous Ovarian Hyperstimulation Syndrome Mimicking Ovarian Cancer in a Nonpregnant Woman: A Case Report and Literature Review Publisher Pubmed



Akhavan S1 ; Daraei M2 ; Salahshour F3, 4 ; Mosavat MS1
Authors
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Authors Affiliations
  1. 1. Vali-e-Asr Reproductive Health Research Center, Family Health Research Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran
  2. 2. Internal Medicine Department of Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran
  3. 3. Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Iran
  4. 4. Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran

Source: Journal of International Medical Research Published:2025


Abstract

Spontaneous ovarian hyperstimulation syndrome is an extremely rare condition, especially in nonpregnant women who do not exhibit exogenous ovarian stimulation. Herein, we present a case of spontaneous ovarian hyperstimulation syndrome in a 28-year-old nonpregnant woman who presented with life-threatening multiorgan dysfunction. Initial imaging studies and tumor marker assessment suggested the presence of a malignant ovarian tumor, posing substantial diagnostic challenges. The patient underwent emergency surgery due to severe hemorrhagic shock. Intraoperative findings revealed irregular and deformed ovaries; however, histologic examination showed luteinizing hemorrhagic cysts, leading to a diagnosis of spontaneous ovarian hyperstimulation syndrome. This case highlights the importance of considering spontaneous ovarian hyperstimulation syndrome in the differential diagnosis of ovarian enlargement with ascites, even in the absence of pregnancy or ovarian stimulation. It also underscores the critical role of expert radiological interpretation in such complex cases. © The Author(s) 2025.