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An Eco-Friendly Synthesis of 4-Aryl-Substituted Pyrano-Fuzed Coumarins As Potential Pharmacological Active Heterocycles Using Molybdenum Oxide Nanoparticles As an Effective and Recyclable Catalyst Publisher



Pourshojaei Y1, 2 ; Jadidi MH1 ; Eskandari K1 ; Foroumadi A2, 3 ; Asadipour A1
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Research on Chemical Intermediates Published:2018


Abstract

A green cascade three-component reaction between 4-hydroxycoumarin, malononitrile and a wide range of arylaldehydes by employing molybdenum oxide nanoparticles (MoO3 NPs) is described. By this achievement, some medicinally important products have been successfully synthesized in a one-pot under green conditions. Obtaining good to excellent yields of products, environmentally benign procedure, being easily handled, availability of starting materials, use of non-toxic solvents, and high recyclability of nano-catalysts are the most important advantages of this methodology. © 2018, Springer Science+Business Media B.V., part of Springer Nature.