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Reductionism and Proxy Failure: From Neuroscience to Target-Based Drug Discovery Publisher Pubmed



Sadri A1, 2 ; Paknezhad S3
Authors
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Authors Affiliations
  1. 1. Lyceum Scientific Charity, Tehran, Iran
  2. 2. Interdisciplinary Neuroscience Research Program (INRP), Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Psychology, Sari Branch, Islamic Azad University, Sari, Iran

Source: Behavioral and Brain Sciences Published:2024


Abstract

Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge further from the original object of study. We vividly illustrate this in the evolution of target-based drug discovery from rational and phenotypic drug discovery. Copyright © The Author(s), 2024. Published by Cambridge University Press.
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