Comparison of the Analgesic Effects of a Mixture of Lidocaine and Epinephrin With Those of a Mixture of Lidocaine and Bicarbonate for Local Anesthesia



Forouzan A¹ ; Darian AA¹ ; Masoumi K¹ ; Vaseie F¹ ; Vaseie M² Show Affiliations
Source: International Journal of Pharmacy and Technology Published:2016

Abstract

Study’s background and aim: Because pain cautions of tissue damage, humans attempt to find ways to overcome pain. Lidocaine is one of the most common pharmacological agents used for local anesthesia. Materials and methods: With regard to the literature evidence, adding epinephrine and bicarbonate to lidocaine further reduces pain and prolongs the analgesia. The aim of the present study was to compare the analgesic effects of a mixture of lidocaine and epinephrine with those of a mixture of lidocaine and bicarbonate for local anesthesia in scalp lacerations. The study was conducted as a double-blinded clinical trial. The sample comprised 92 individuals; the level of anesthesia was determined on the basis of visual analog scale scores. Results: Pain levels were significantly different at the time of injection, 5 min later and 10 min later. The P value was 0.1 at the time of injection, 0.001 at 5 min after injection and 0.003 at 10 min after injection. Conclusion: The results indicate that pain levels during the suturing of scalp lacerations are lower while using lidocaine together with epinephrine compared with those while using lidocaine and bicarbonate. This difference is statistically significant. © 2016, International Journal of Pharmacy and Technology. All rights reserved.