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Potential Therapeutic Options for Covid-19: An Update on Current Evidence Publisher Pubmed



Niknam Z1 ; Jafari A2 ; Golchin A3 ; Danesh Pouya F4 ; Nemati M4 ; Rezaeitavirani M5 ; Rasmi Y4, 6
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  3. 3. Department of Clinical Biochemistry and Applied Cell Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  4. 4. Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  5. 5. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

Source: European Journal of Medical Research Published:2022


Abstract

SARS-CoV-2, a novel coronavirus, is the agent responsible for the COVID-19 pandemic and is a major public health concern nowadays. The rapid and global spread of this coronavirus leads to an increase in hospitalizations and thousands of deaths in many countries. To date, great efforts have been made worldwide for the efficient management of this crisis, but there is still no effective and specific treatment for COVID-19. The primary therapies to treat the disease are antivirals, anti-inflammatories and respiratory therapy. In addition, antibody therapies currently have been a many active and essential part of SARS-CoV-2 infection treatment. Ongoing trials are proposed different therapeutic options including various drugs, convalescent plasma therapy, monoclonal antibodies, immunoglobulin therapy, and cell therapy. The present study summarized current evidence of these therapeutic approaches to assess their efficacy and safety for COVID-19 treatment. We tried to provide comprehensive information about the available potential therapeutic approaches against COVID-19 to support researchers and physicians in any current and future progress in treating COVID-19 patients. © 2022, The Author(s).
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