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Synthesis of Novel Tetracyclic Coumarin-Fused Furo-Pyridone Scaffolds Via Sequential N-Arylation and Intramolecular Amidation Reactions Publisher



Adib M1 ; Ghanbarlou M1 ; Soheilizad M2 ; Bahadorikhalili S3 ; Larijani B3 ; Mahdavi M3
Authors

Source: Tetrahedron Letters Published:2021


Abstract

An efficient synthesis of 4H-chromeno[4,3-b]furo[2,3-d]pyridine-1-carboxylates as novel tetracyclic coumarin-fused furo-pyridone scaffolds is described. The protocol involves the three-component reaction of 4-chloro-coumarin-3-carbaldehyde, dimethyl acetylenedicarboxylate and isocyanides, followed by the addition of primary amines to produce the corresponding products in 78–92% yield. © 2021