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Combinatorial Biosynthesis: Playing Chess With the Metabolism Publisher Pubmed



Danaeifar M1 ; Mazlomi MA1
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran

Source: Journal of Asian Natural Products Research Published:2023


Abstract

Secondary metabolites are a group of natural products that produced by bacteria, fungi and plants. Many applications of these compounds from medicine to industry have been discovered. However, some changes in their structure and biosynthesis mechanism are necessary for their properties to be more suitable and also for their production to be profitable. The main and most useful method to achieve this goal is combinatorial biosynthesis. This technique uses the multi-unit essence of the secondary metabolites biosynthetic enzymes to make changes in their order, structure and also the organism that produces them. © 2022 Informa UK Limited, trading as Taylor & Francis Group.