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Data on Cell Survival, Apoptosis, Ceramide Metabolism and Oxidative Stress in A-494 Renal Cell Carcinoma Cell Line Treated With Hesperetin and Hesperetin-7-O-Acetate Publisher



Boojar MMA1, 2 ; Boojar MMA1, 2 ; Golmohammad S3 ; Bahrehbar I3
Authors

Source: Data in Brief Published:2018


Abstract

Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide metabolism. Our data represent the comparative assessment of Hesperetin (Hst) and hesperetin-7-O-acetate (HTA) effects on A-494 renal carcinoma cells include cell survival, caspase-3 and 9 activities, total cellular ceramide and the activities of ACDase, NSMase, GCS and superoxide dismutase (SOD). Data reveals potentiating effects of both HTA and Hst on ceramide pathway and may offer a novel tool in human renal cell carcinoma therapy. © 2018 The Authors