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Factors Associated With Health-Related Quality of Life in Patients With Crohn's Disease in Iran: A Prospective Observational Study Publisher



Karami H1 ; Shirvani Shiri M2 ; Ebadi Fard Azar F3 ; Bagheri Lankarani K4 ; Ghahramani S4 ; Rezapour A5 ; Tatari M6, 7 ; Heidari Javargi Z8
Authors
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Authors Affiliations
  1. 1. Department of Economics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Fars, Shiraz, Iran
  5. 5. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Vice Chancellery of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  8. 8. Department of Clinical Medicine, School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Frontiers in Medicine Published:2023


Abstract

This was a 1-year prospective observational study of the health-related quality of life (HRQoL) of moderate to severe crohn's disease (CD) patients in Iran. Patients' HRQoL were measured using the EQ-5D 3L, EQ-VAS, and IBDQ-9 tools. HRQoL among CD patients were compared using the T-test, Mann–Whitney, Chi-square, and Fisher's exact tests. To discover factors influencing patients' HRQoL, multivariate linear regression and multivariate logistic regression tests were utilized. The study included 222 CD patients, with a mean age of 34.67 and mean disease duration of 7.32 years. The dimensions with the worst reported “relatively or extreme problems” were P/D: 77.5% and A/D: 63.1%. Employment, having “other chronic diseases,” and ADA consumption were the most important independent predictors of HRQoL in CD patients, [β = 0.21 (EQ-5D index), β = 19.61 (EQ-VAS), β = 12.26 (IBDQ-9), OR: 0.09 (MO), OR: 0.12 (UA), OR: 0.21 (P/D), OR: 0.22 (A/D)], [β = −0.15 (EQ-5D index), β = −5.84 (IBDQ-9), β = −11.06 (EQ-VAS), OR: 4.20 (MO), OR: 6.50 (UA)], and [OR: 2.29 (A/D)], respectively. Unemployment, presence of “other chronic conditions” had the greatest negative impact on HRQoL of CD patients. There were significant differences in the probability of reporting “relatively or extreme problems” in the SC and A/D dimensions between patients using adalimumab (ADA) and infliximab (IFX). Copyright © 2023 Karami, Shirvani Shiri, Ebadi Fard Azar, Bagheri Lankarani, Ghahramani, Rezapour, Tatari and Heidari Javargi.
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