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Molecular Investigation of Coxiella Burnetii and Bartonella in Heart Valve Specimens of Patients With Endocarditis in Iran Publisher Pubmed



Latifian M1, 2 ; Mostafavi E1, 2 ; Broumand MA3, 4 ; Bagheri Amiri F2 ; Mohammadi MR2, 5 ; Esmaeili S1, 2
Authors
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Authors Affiliations
  1. 1. National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran
  2. 2. Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Pathology and Laboratory Medicine, Tehran Heart Center Tehran, University of Medical Sciences, Tehran, Iran
  4. 4. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Journal of Infection and Public Health Published:2025


Abstract

Background: Infective endocarditis (IE), is a medical condition that threatens human health. The aim of this study is the molecular investigation of Coxiella burnetii and Bartonella spp. in heart valves in Iran. Methods: In this study, 146 patients with pathological evidence of IE and underwent heart valve surgery between 2016 and 2020 were selected. Furthermore, positive samples for C. burnetii were genotyped by the Multi Spacers Typing (MST) method, and positive samples for Bartonella were sequenced on the 16SrRNA gene. Results: 12 patients (8.2 %) were identified as positive cases of C. burnetii, and two novel genotypes of C. burnetii were identified using MST genotyping. Additionally, 15 patients (10.3 %) were diagnosed with Bartonella endocarditis, and all positive cases were identified as Bartonella quintana. Conclusion: According to the identification of positive cases of Q fever endocarditis and Bartonella endocarditis, future studies in this field are suggested to focus on elucidating methods of prevention, diagnosis and treatment. © 2024 The Authors
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2. Molecular Diagnosis of Infective Endocarditis From Culture-Negative Valve Samples in a Tertiary Hospital in Iran, Microbiology Spectrum (2025)
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