The Association Between Obesity With Treatment Duration, Icu Length of Stay and the Risk of Death in Critically Ill Patients With Covid-19 Publisher Pubmed



Gholamalizadeh M¹ ; Attari M² ; Mousavi M³ ; Shekari S⁴ ; Salimi Z⁵ ; Rajabiharsini A⁶ ; Zeinolabedin M⁷ ; Barzkar A⁸ ; Mahmoudi Z⁴ ; Alami F⁹ ; Dahka SM¹⁰ ; Gholami S¹¹ ; Rahvar M¹² ; Pourtaleb M¹² Show All Authors Show Affiliations
Source: Endocrinology# Diabetes and Metabolism Published:2023

Abstract

Background: Despite the confirmed association between higher BMI with increased risk of the acute respiratory distress syndrome (ARDS), the association between obesity with mortality in critically ill patients with coronavirus disease 2019 (COVID-19) is not clear. The present study aimed to investigate the association between obesity with treatment duration, ICU length of stay, and the risk of death in critically ill patients with COVID-19. Methods: This case–control study was performed on 223 patients with COVID-19 including 148 surviving patients as the control group and 75 eventually dead patients as the case group in Rasht, Iran. Data on demographic factors, comorbidities, anthropometric measurements, the length of hospitalization and the mortality were obtained from patients' medical records. Results: The mortality rate was significantly associated with weight (OR = 1.04, 95% CI: 1.002–1.083, p =.04), but not with BMI after adjustments for age, gender, length of stay in ICU, chronic diseases and smoking. The results did not change after further adjustments for biochemical and pathological factors. Conclusions: Weight was positively associated with mortality after controlling for confounding variables. Further studies should consider the patient's body composition such as fat mass to establish the relationship between obesity and COVID-19 outcomes. © 2023 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.