Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents

Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents Publisher

Rahimnia R¹ ; Rezayat SM¹ ; Torabi R² ; Soltanghoraee H³ ; Mehravi B⁴ ; Amani A¹ ; Kharrazi S¹ ; Amanlou M^{5, 6}

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1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Nanobiomedicine Center of Excellence, Nanoscience and Nanotechnology Research Center, University of Tehran, Tehran, Iran
3. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
4. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Genetics and Molecular Research Published:2018

Abstract

Gold nanoparticles (GNPs) with controlled geometric properties are new options for the management of inflammatory responses and therapy for various diseases, including diabetes mellitus, rheumatoid arthritis, and connective tissue diseases. We examined anti-inflammatory impacts of sugar coated GNPs with different sizes on carrageenan-induced rat paw inflammation. The synthesized GNPs were compared with indomethacin, methotrexate and the commercial gold preparation myochrysine. While methotrexate and myochrysine did not have any significant effects on rat paws, GNPs significantly decreased the inflammatory responses, comparable with indomethacin, a standard anti-inflammatory drug in the rat paw model. There was no harmful effect on metabolic activity of cells treated with GNPs of different sizes. We conclude that sugar coated GNPs are a promising candidate for new options in the management of inflammatory-related diseases. © FUNPEC-RP.

Style	Citing Format
MLA	Rahimnia R, et al.. "Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents." Genetics and Molecular Research, vol. 17, no. 4, 2018, pp. -.
APA	Rahimnia R, Rezayat SM, Torabi R, Soltanghoraee H, Mehravi B, Amani A, Kharrazi S, Amanlou M (2018). Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents. Genetics and Molecular Research, 17(4), -.
Chicago	Rahimnia R, Rezayat SM, Torabi R, Soltanghoraee H, Mehravi B, Amani A, Kharrazi S, Amanlou M. "Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents." Genetics and Molecular Research 17, no. 4 (2018): -.
Harvard	Rahimnia R et al. (2018) 'Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents', Genetics and Molecular Research, 17(4), pp. -.
Vancouver	Rahimnia R, Rezayat SM, Torabi R, Soltanghoraee H, Mehravi B, Amani A, et al.. Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents. Genetics and Molecular Research. 2018;17(4):-.
BibTex	@article{ author = {Rahimnia R and Rezayat SM and Torabi R and Soltanghoraee H and Mehravi B and Amani A and Kharrazi S and Amanlou M}, title = {Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents}, journal = {Genetics and Molecular Research}, volume = {17}, number = {4}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Rahimnia R AU - Rezayat SM AU - Torabi R AU - Soltanghoraee H AU - Mehravi B AU - Amani A AU - Kharrazi S AU - Amanlou M TI - Gold Nanoparticle Sucrose Complexes As Potent Anti-Inflammatory Agents JO - Genetics and Molecular Research VL - 17 IS - 4 SP - EP - PY - 2018 ER -

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