Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents

Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents Publisher

Almasirad A³ ; Firoozpour L¹ ; Nejati M¹ ; Edraki N⁴ ; Firuzi O⁴ ; Khoshneviszadeh M⁴ ; Mahdavi M² ; Moghimi S² ; Safavi M⁵ ; Shafiee A² ; Foroumadi A^{1, 2}

Show Affiliations

1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
4. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5. Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran

Source: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences Published:2016

Abstract

A series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol- 2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

Style	Citing Format
MLA	Almasirad A, et al.. "Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 71, no. 3, 2016, pp. 205-210.
APA	Almasirad A, Firoozpour L, Nejati M, Edraki N, Firuzi O, Khoshneviszadeh M, Mahdavi M, Moghimi S, Safavi M, Shafiee A, Foroumadi A (2016). Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 71(3), 205-210.
Chicago	Almasirad A, Firoozpour L, Nejati M, Edraki N, Firuzi O, Khoshneviszadeh M, Mahdavi M, et al.. "Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 71, no. 3 (2016): 205-210.
Harvard	Almasirad A et al. (2016) 'Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents', Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 71(3), pp. 205-210.
Vancouver	Almasirad A, Firoozpour L, Nejati M, Edraki N, Firuzi O, Khoshneviszadeh M, et al.. Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 2016;71(3):205-210.
BibTex	@article{ author = {Almasirad A and Firoozpour L and Nejati M and Edraki N and Firuzi O and Khoshneviszadeh M and Mahdavi M and Moghimi S and Safavi M and Shafiee A and Foroumadi A}, title = {Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents}, journal = {Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences}, volume = {71}, number = {3}, pages = {205-210}, year = {2016} }
RIS	TY - JOUR AU - Almasirad A AU - Firoozpour L AU - Nejati M AU - Edraki N AU - Firuzi O AU - Khoshneviszadeh M AU - Mahdavi M AU - Moghimi S AU - Safavi M AU - Shafiee A AU - Foroumadi A TI - Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences VL - 71 IS - 3 SP - 205 EP - 210 PY - 2016 ER -

Style

Citing Format

MLA

Almasirad A, et al.. "Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 71, no. 3, 2016, pp. 205-210.

APA

Almasirad A, Firoozpour L, Nejati M, Edraki N, Firuzi O, Khoshneviszadeh M, Mahdavi M, Moghimi S, Safavi M, Shafiee A, Foroumadi A (2016). Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 71(3), 205-210.

Chicago

Almasirad A, Firoozpour L, Nejati M, Edraki N, Firuzi O, Khoshneviszadeh M, Mahdavi M, et al.. "Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 71, no. 3 (2016): 205-210.

Harvard

Almasirad A et al. (2016) 'Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents', Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 71(3), pp. 205-210.

Vancouver

Almasirad A, Firoozpour L, Nejati M, Edraki N, Firuzi O, Khoshneviszadeh M, et al.. Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 2016;71(3):205-210.

BibTex

@article{ author = {Almasirad A and Firoozpour L and Nejati M and Edraki N and Firuzi O and Khoshneviszadeh M and Mahdavi M and Moghimi S and Safavi M and Shafiee A and Foroumadi A}, title = {Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents}, journal = {Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences}, volume = {71}, number = {3}, pages = {205-210}, year = {2016} }

RIS

TY - JOUR
AU - Almasirad A
AU - Firoozpour L
AU - Nejati M
AU - Edraki N
AU - Firuzi O
AU - Khoshneviszadeh M
AU - Mahdavi M
AU - Moghimi S
AU - Safavi M
AU - Shafiee A
AU - Foroumadi A
TI - Design, Synthesis, and Biological Evaluation of New Series of 2-Amido-1,3,4-Thiadiazole Derivatives As Cytotoxic Agents
JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
VL - 71
IS - 3
SP - 205
EP - 210
PY - 2016
ER -

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