A Systematic Review of Resting-State and Task-Based Fmri in Juvenile Myoclonic Epilepsy Publisher Pubmed



Sanjari Moghaddam H^{1, 2, 3} ; Sanjari Moghaddam A⁴ ; Hasanzadeh A^{1, 2} ; Sanatian Z¹ ; Mafi A^{1, 2} ; Aarabi MH⁵ ; Samimi M¹ ; Aghamollaii V¹ ; Gholipour T⁶ ; Tafakhori A¹ Show Affiliations
Source: Brain Imaging and Behavior Published:2022

Abstract

Functional neuroimaging modalities have enhanced our understanding of juvenile myoclonic epilepsy (JME) underlying neural mechanisms. Due to its non-invasive, sensitive and analytical nature, functional magnetic resonance imaging (fMRI) provides valuable insights into relevant functional brain networks and their segregation and integration properties. We systematically reviewed the contribution of resting-state and task-based fMRI to the current understanding of the pathophysiology and the patterns of seizure propagation in JME Altogether, despite some discrepancies, functional findings suggest that corticothalamo-striato-cerebellar network along with default-mode network and salience network are the most affected networks in patients with JME. However, further studies are required to investigate the association between JME’s main deficiencies, e.g., motor and cognitive deficiencies and fMRI findings. Moreover, simultaneous electroencephalography-fMRI (EEG-fMRI) studies indicate that alterations of these networks play a role in seizure modulation but fall short of identifying a causal relationship between altered functional properties and seizure propagation. This review highlights the complex pathophysiology of JME, which necessitates the design of more personalized diagnostic and therapeutic strategies in this group. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.