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Plant-Derived Molecules for the Prevention and Treatment of Mitochondria-Related Diseases Publisher



Asghari MH1 ; Moloudizargari M2 ; Abdollahi M3
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  2. 2. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health Published:2021


Abstract

Mitochondria play a central role within the cells and are known as a cellular powerhouse. Mitochondrial deficits may initiate primarily from mutations in mitochondrial DNA (mtDNA) or mitochondrial nuclear genes and secondarily by the defects in other functional and structural aspects of mitochondria, which lead to common conditions such as metabolic defects and diseases. Accordingly, targeting mitochondria and enhancing mitochondrial function could be a promising way to treat these diseases. Serving as an essential source of new drugs, herbs have enabled the discovery of many novel therapeutic agents for the treatment and prevention of diseases in the past decades. Herein, we discuss herbals and plant-derived molecules with effects on mitochondria and its related pathologies, which can potentially be used as adjuvant therapeutics. © 2021 Elsevier Inc. All rights reserved.
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