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The Other Side of the Coin: Positive View on the Role of Opioids in Cancer Publisher Pubmed



Patrad E1 ; Khalighfard S2 ; Khori V3 ; Alizadeh AM1, 4
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Breast Disease Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Pharmacology Published:2022


Abstract

Opioids have been used for medicinal purposes as an analgesic and recreational purposes as a euphorigenic throughout human history. Cancer patients are often treated with different doses of opioids concurrently with anti-cancer drugs for pain relief without exhibiting excessive adverse effects. The intersection of the biology of pain, opioid therapy, and disease progression represents the crux of the matters and is of potentially great importance in cancer care. For more than 20 years, multiple investigations have focused on the stimulatory effects of opioids on cancer cell growth, while in-depth studies on the inhibitory effects on cancer cell growth development have usually been neglected. This paper reviews the evidence regarding opioid therapies and their anti-cancer effects on various malignancies. Likewise, we have a glimpse into the molecular mechanisms necessary for pinpointing their positive or negative impacts on malignancies to raise awareness and stimulate more excellent dialogue regarding their carcinogenic/anticarcinogenic roles. © 2022 Elsevier B.V.
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