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Molecular Detection of Adeno-Associated Virus Dna in Cases of Spontaneous and Therapeutic Abortion Publisher Pubmed



Sayyadidehno Z1 ; Seyed Khorrami SM2 ; Ghavami N1 ; Ghotbizadeh F3 ; Khushideh M3 ; Hosseini M4 ; Malekshahi SS2 ; Shafieijandaghi NZ1
Authors
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Authors Affiliations
  1. 1. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Obstetrics and gynecology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Fetal and Pediatric Pathology Published:2019


Abstract

Background: Adeno-associated viruses (AAVs) have been found in human blood cells, cervical biopsies, and epithelial cell brushings, endometrium, and abortion material, which suggest their possible roles in the induction of miscarriage. Objective: In this case control study, the presence of AAV DNA in placental tissue of spontaneous and therapeutic abortions was compared. Method: Placenta samples were evaluated for AAV DNA by hemi-nested PCR in miscarriages occurring in the first 24 weeks of pregnancy from therapeutic and spontaneous abortions. Results: Eighty-one therapeutic abortions (control group) and 83 spontaneous abortions (case group) were evaluated. Sixty-two (38.2%) of 164 abortions were AAV positive, including 35 (21.6%) spontaneous abortions and 27 (16.6%) therapeutic abortions. Conclusion: There was no statistically significant difference between the presence of the AAV genome in spontaneous and therapeutic abortions. This observation was consistent with other studies in this area. © 2019, © 2019 Taylor & Francis Group, LLC.