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Lipid Profile Scores Predict Severity of Pemphigus: A Cross-Sectional Study Publisher



Fallah M1 ; Najafi A2 ; Ranjbar M1 ; Balighi K3, 4 ; Daneshpazhooh M3, 4 ; Ebrahimpourkoujan S1
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Indian Journal of Dermatology Published:2025


Abstract

There is little evidence about the relationship between lipid indices and the severity of pemphigus vulgaris (PV) disease. In this cross sectional study, we try to find out the exact relationship between three dietary lipid indices (PUFA/SFA ratio and ω 6/ω 3 index) and the severity of PV disease. Methods: In this hospital based cross sectional study, a total of 138 pemphigus vulgaris cases were studied, of which 108 had PDAI ≤15, and 30 had PDAI>15. Dietary intakes were measured a valid 168 item FFQ. To calculate the lipid indices, the data received from diet were used. Results: After adjusting for potential confounders, people with the highest ω 6/ω 3 index had 32% lowest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 0.68; 95% CI: 0.24-1.93, P trend= 0.47). Moreover, people with the highest PUFA/SFA index had 9% highest severity of PV disease compared to the people in the lowest category. However, this association was not significant in all models (OR: 1.09; 95% CI: 0.34-3.51, P trend = 0.88). Conclusion: The evidence of our study shows that the relation between PUFA/SFA ratio and ω 6/ω 3 index is not significant. However, case-control studies are needed to confirm these findings. © 2024 Indian Journal of Dermatology.
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