Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation Publisher

Maffini E ; Ngoya M ; Houhou M ; Benakli M ; Bahar B ; Aljurf M ; Halahleh K ; Peffault De Latour R ; Blau I W ; Clark A ; Flynn C ; Remenyi P P ; Maroto M L ; Yakoub Agha I Show All Authors

Maffini E
Ngoya M
Houhou M
Benakli M
Bahar B
Aljurf M
Halahleh K
Peffault De Latour R
Blau I W
Clark A
Flynn C
Remenyi P P
Maroto M L
Yakoub Agha I
Sengeloev H
Castilla Llorente C
Nicholson E
Salmenniemi U
Vrhovac R
Passweg J
Eder M
Daguindau E
Spyridonidis A
Nagler A
Ciceri F
Mohty M

Source: Bone Marrow Transplantation Published:2026

Abstract

The optimal myeloablative conditioning regimen for adolescents and young adults with acute myeloid leukaemia (AML) is currently unknown. In this retrospective analysis conducted on AML patients aged 18-40 years, in complete remission (CR), who received an allogeneic hematopoietic cell transplantation (HCT) we compared outcomes of different conditioning regimens. A total of 4323 patients, with median age of 30.9 years, transplanted from 2010 to 2022, received one of four regimens: high-dose total body irradiation (TBI)-based (n = 1031), thiotepa-busulfan (Bu)-fludarabine (Flu) (TBF) n = 219, Bu-Flu (n = 1100), and Bu-cyclophosphamide (Cy) (n = 1973). Prolonged OS and PFS for Bu-Flu (hazard ratio [HR] 0.73, 95% CI 0.57–0.92, p = 0.008; HR 0.78, 95% CI 0.64–0.94, p = 0.01), and TBF (HR 0.59, 95% CI 0.38-0.92, p = 0.02; HR 0.67, 95% CI 0.47–0.94, p = 0.02), respectively, as well as less RI for both Bu-Flu (HR 0.77, 95% CI 0.63–0.95, p = 0.01), and TBF (HR 0.68, 95% CI 0.47–0.99, p = 0.046). In conclusion, young adult AML patients seem to benefit from high dose TBI-free regimens, in terms of survival and toxicity, with four major myeloablative regimens. TBF and Bu-Flu were associated with better clinical outcomes, partly reflecting the general improvement in supportive therapies and patient selection introduced in recent years. Prospective clinical trials are warranted. © The Author(s), under exclusive licence to Springer Nature Limited 2026.

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Style	Citing Format
MLA	Maffini E, et al.. "Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation." Bone Marrow Transplantation, vol. , no. , 2026, pp. -.
APA	Maffini E, Ngoya M, Houhou M, Benakli M, Bahar B, Aljurf M, Halahleh K, Peffault De Latour R, Blau I W, Clark A, Flynn C, Remenyi P P, Maroto M L, Yakoub Agha I, Sengeloev H, Castilla Llorente C, Nicholson E, Salmenniemi U, Vrhovac R, ... Mohty M (2026). Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplantation, (), -.
Chicago	Maffini E, Ngoya M, Houhou M, Benakli M, Bahar B, Aljurf M, Halahleh K, et al.. "Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation." Bone Marrow Transplantation , no. (2026): -.
Harvard	Maffini E et al. (2026) 'Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation', Bone Marrow Transplantation, (), pp. -.
Vancouver	Maffini E, Ngoya M, Houhou M, Benakli M, Bahar B, Aljurf M, et al.. Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplantation. 2026;():-.
BibTex	@article{ author = {Maffini E and Ngoya M and Houhou M and Benakli M and Bahar B and Aljurf M and Halahleh K and Peffault De Latour R and Blau I W and Clark A and Flynn C and Remenyi P P and Maroto M L and Yakoub Agha I and Sengeloev H and Castilla Llorente C and Nicholson E and Salmenniemi U and Vrhovac R and Passweg J and Eder M and Daguindau E and Spyridonidis A and Nagler A and Ciceri F and Mohty M}, title = {Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation}, journal = {Bone Marrow Transplantation}, volume = {}, number = {}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Maffini E AU - Ngoya M AU - Houhou M AU - Benakli M AU - Bahar B AU - Aljurf M AU - Halahleh K AU - Peffault De Latour R AU - Blau I W AU - Clark A AU - Flynn C AU - Remenyi P P AU - Maroto M L AU - Yakoub Agha I AU - Sengeloev H AU - Castilla Llorente C AU - Nicholson E AU - Salmenniemi U AU - Vrhovac R AU - Passweg J AU - Eder M AU - Daguindau E AU - Spyridonidis A AU - Nagler A AU - Ciceri F AU - Mohty M TI - Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation JO - Bone Marrow Transplantation VL - IS - SP - EP - PY - 2026 ER -

Style

Citing Format

MLA

Maffini E, et al.. "Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation." Bone Marrow Transplantation, vol. , no. , 2026, pp. -.

APA

Maffini E, Ngoya M, Houhou M, Benakli M, Bahar B, Aljurf M, Halahleh K, Peffault De Latour R, Blau I W, Clark A, Flynn C, Remenyi P P, Maroto M L, Yakoub Agha I, Sengeloev H, Castilla Llorente C, Nicholson E, Salmenniemi U, Vrhovac R, ... Mohty M (2026). Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplantation, (), -.

Chicago

Maffini E, Ngoya M, Houhou M, Benakli M, Bahar B, Aljurf M, Halahleh K, et al.. "Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation." Bone Marrow Transplantation , no. (2026): -.

Harvard

Maffini E et al. (2026) 'Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation', Bone Marrow Transplantation, (), pp. -.

Vancouver

Maffini E, Ngoya M, Houhou M, Benakli M, Bahar B, Aljurf M, et al.. Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Bone Marrow Transplantation. 2026;():-.

BibTex

@article{ author = {Maffini E and Ngoya M and Houhou M and Benakli M and Bahar B and Aljurf M and Halahleh K and Peffault De Latour R and Blau I W and Clark A and Flynn C and Remenyi P P and Maroto M L and Yakoub Agha I and Sengeloev H and Castilla Llorente C and Nicholson E and Salmenniemi U and Vrhovac R and Passweg J and Eder M and Daguindau E and Spyridonidis A and Nagler A and Ciceri F and Mohty M}, title = {Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation}, journal = {Bone Marrow Transplantation}, volume = {}, number = {}, pages = {-}, year = {2026} }

RIS

TY - JOUR
AU - Maffini E
AU - Ngoya M
AU - Houhou M
AU - Benakli M
AU - Bahar B
AU - Aljurf M
AU - Halahleh K
AU - Peffault De Latour R
AU - Blau I W
AU - Clark A
AU - Flynn C
AU - Remenyi P P
AU - Maroto M L
AU - Yakoub Agha I
AU - Sengeloev H
AU - Castilla Llorente C
AU - Nicholson E
AU - Salmenniemi U
AU - Vrhovac R
AU - Passweg J
AU - Eder M
AU - Daguindau E
AU - Spyridonidis A
AU - Nagler A
AU - Ciceri F
AU - Mohty M
TI - Impact of Conditioning Regimen on Outcomes of Young Aml Patients ( < 40 Years) Undergoing Hct in Complete Remission, With Transplant Conditioning Intensity Score of 3.5-4.0. a Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
JO - Bone Marrow Transplantation
VL -
IS -
SP -
EP -
PY - 2026
ER -

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