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Phenotypic Evaluation of Strains of Candida Albicans and Non-Albicans Candida Species in Patients With Vulvovaginal Candidiasis Visiting Amir-Al-Momenin Hospital in Zabol, Iran in 2019 Publisher



Fouladi B1 ; Keikhaie KR2 ; Ghaemi M3, 4 ; Shirazi M3, 5 ; Ahmadian M3 ; Nikoo NR5 ; Poya SA1 ; Saravani S1 ; Farzi J6
Authors
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Authors Affiliations
  1. 1. Department of Parasitology and Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  2. 2. Department of Obstetrics and Gynecology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  3. 3. Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Kamali Hospital, Alborz University of Medical Sciences, Tehran, Karaj, Iran
  5. 5. Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Shohada Hospital, Qom University of Medical Sciences, Qom, Iran

Source: Journal of Obstetrics# Gynecology and Cancer Research Published:2020


Abstract

Background & Objective: Vulvovaginal candidiasis (VVC) is a common vaginal yeast infection in women. The present study aimed to determine the phenotype of Candida albicans and non-albicans Candida species in VVC cases. Materials & Methods: This was a cross-sectional study on 65 patients suspected of VVC through a visit by a gynecologist. They were cultured on CHROMagar and Sabouraud dextrose agar (SDA). If morphology of the colonies could be detected through microscopic inspection, physiological tests were used to identify individual yeast species. Results: Out 65 colonies, 53.8% had negative cultures. The frequency of positive cultures for Candida were also calculated (C. albicans = 38.5%, C. glabrata = 6.15%, and C. krusei = 1.53%). Most of culture-negative cases had no history of antibiotic therapy (94.3%) while most of culture-positive cases had a history of fluconazole therapy (56% in C. albicans isolates and 40% in non-C. albicans isolates). Relapse rate was calculated as 29.2%. Of studied patients, 80% had no underlying disease, 15.4% had a history of diabetes, and 4.6% had a history of corticosteroid therapy. Less than half negative-culture cases had an undergraduate degree (45.7%). Conclusion: The incidence of VVC depends on various factors including occupation, underlying disease and history of antibiotic therapy. The most common cause of VVC is C. glabrata, secondary to C. albicans. Relapse infection rates can be reduced by increasing knowledge on clinical data, underlying diseases, mechanism of the organism, cause of infection, and effective treatment. © 2020, Farname Inc. All rights reserved.
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1. Molecular Epidemiology and in Vitro Antifungal Susceptibility of Candida Isolates Fromwomen With Vulvovaginal Candidiasis in Northern Cities of Khuzestan Province, Iran, Jundishapur Journal of Microbiology (2017)
2. Vulvovaginal Candidiasis in Iran: A Systematic Review and Meta-Analysis on the Epidemiology, Clinical Manifestations, Demographic Characteristics, Risk Factors, Etiologic Agents and Laboratory Diagnosis, Microbial Pathogenesis (2021)
3. Identification of Candida Species by Molecular and Mycological Methods in Pregnant Women With Vulvovaginal Candidiasis, Tehran University Medical Journal (2018)
4. Vulvovaginal Candidiasis: An Overview of Mycological, Clinical, and Immunological Aspects, Journal of Obstetrics and Gynaecology Research (2022)
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