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The Recent Advancements in the Early Detection of Cancer Biomarkers by Dnazyme-Assisted Aptasensors Publisher Pubmed



Kamali H1, 3 ; Golmohammadzadeh S2, 3 ; Zare H4 ; Nosrati R5 ; Fereidouni M6 ; Safarpour H6
Authors
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Authors Affiliations
  1. 1. Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  5. 5. Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  6. 6. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran

Source: Journal of Nanobiotechnology Published:2022


Abstract

Abstract: Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays a crucial role in the subsequent treatments. There are several different detection techniques available today for detecting cancer biomarkers. Because of target-related conformational alterations, high stability, and target variety, aptamers have received considerable interest as a biosensing system component. To date, several sensitivity-enhancement strategies have been used with a broad spectrum of nanomaterials and nanoparticles (NPs) to improve the limit and sensitivity of analyte detection in the construction of innovative aptasensors. The present article aims to outline the research developments on the potential of DNAzymes-based aptasensors for cancer biomarker detection. Graphical Abstract: [Figure not available: see fulltext.]. © 2022, The Author(s).