Coagulation Factor Xiii-A A614t Gene Variation Is Suggestive of Founder Effect in Iranian Patients With Sever Congenital Factor Xiii Deficiency Publisher



Naderi M¹ ; Tabibian S² ; Alizadeh S² ; Abtahi ZS² ; Dorgalaleh A³
Source: Journal of Cellular and Molecular Anesthesia Published:2016

Abstract

Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in FXIII-A gene with obvious ethnic difference. This study assessed prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for T allele at codon 204 of FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect. © 2016 Shahid Beheshti University of Medical Sciences,  Anesthesiology Research Center. All Rights Reserved.