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Coagulation Factor Xiii-A A614t Gene Variation Is Suggestive of Founder Effect in Iranian Patients With Sever Congenital Factor Xiii Deficiency Publisher



Naderi M1 ; Tabibian S2 ; Alizadeh S2 ; Abtahi ZS2 ; Dorgalaleh A3
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics Hematology and Oncology, Ali Ebn-eAbitaleb Hospital Research Center for Children and Adolescents Health [RCCAH], Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Department of Hematology and Blood Transfusion, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular and Molecular Anesthesia Published:2016


Abstract

Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in FXIII-A gene with obvious ethnic difference. This study assessed prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for T allele at codon 204 of FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect. © 2016 Shahid Beheshti University of Medical Sciences,  Anesthesiology Research Center. All Rights Reserved.
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