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Recent Progress of Smart Nano-Based Biosensors and Their Applications in Biomedicine Publisher



Hasanzadeh A1, 2, 3 ; Azmand HR4, 5 ; Ebadati A1, 2, 3 ; Nourizadeh H1, 2, 3 ; Hashemzadeh I1, 2, 3 ; Noori H1, 2, 3 ; Seo SW4 ; Aref AR6 ; Karimi M1, 2, 3, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Electrical Engineering, City College of New York, New York, 10031, NY, United States
  5. 5. Horiba Scientific inc., Piscataway, 08854, NJ, United States
  6. 6. Belfer Center for Applied Cancer Science, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States
  7. 7. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Applied Biotechnology Research Centre, Tehran Medical Science, Islamic Azad University, Tehran, Iran

Source: Nano Published:2022


Abstract

Recent advances in miniaturized nano-based devices are rapidly extending the boundaries of biomedical technologies, particularly biosensors. Highly selective biosensors with the ability to simultaneously detect multiple targets were developed in recent years. The most eye-catching classifications of such biosensors coupled with the emergence of stimuli-responsive and CRISPR/Cas-sensitive systems. Furthermore, attractive features of wearable and implantable biosensors have led to the design of portable, remote controllable diagnostic systems for tackling healthcare challenges in every part of the world, especially in places with limited access to clinical resources. Nevertheless, there are still some barriers to widespread applications of biosensors due mainly to their high costs and the lack of a single biosensing device for highly selective targeting of multiple analytes. Herein, we review the latest developments in biomedical technologies with a focus on biosensors including smart stimuli-responsive, CRISPR/Cas-sensitive, wearable, and implantable biosensors to spark innovations in this field. © 2022 World Scientific Publishing Company.