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Association Between Type 2 Diabetes and Branched Chain Amino Acids (Bcaa); a Case-Control Study Publisher



Torki SA1 ; Bahadori E2 ; Aghakhaninejad Z3 ; Mohseni GK4 ; Tajadod S5 ; Rajabi Harsini A6 ; Azaryan F7 ; Saeedirad Z8 ; Askarpour SA9 ; Mahmoudi Z10 ; Khoshdooz S11 ; Bahar B12 ; Shafaei H13 ; Mosavi Jarrahi SA14 Show All Authors
Authors
  1. Torki SA1
  2. Bahadori E2
  3. Aghakhaninejad Z3
  4. Mohseni GK4
  5. Tajadod S5
  6. Rajabi Harsini A6
  7. Azaryan F7
  8. Saeedirad Z8
  9. Askarpour SA9
  10. Mahmoudi Z10
  11. Khoshdooz S11
  12. Bahar B12
  13. Shafaei H13
  14. Mosavi Jarrahi SA14
  15. Doaei S15
  16. Nazemi S16
  17. Gholamalizadeh M17
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Nutrition, Iran University of Medical Sciences, School of Public Health, International Campus, Tehran, Iran
  6. 6. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  8. 8. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  11. 11. Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport and Health Sciences, University of Central Lancashire, Preston, United Kingdom
  13. 13. Nursing and Midwifery School, Guilan University of Medical Sciences, Rasht, Iran
  14. 14. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  15. 15. Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  16. 16. Cellular and Molecular Research Center, Department of Physiology and Pharmacology, Sabzevar University of Medical Science, Sabzevar, Iran
  17. 17. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2023


Abstract

Background: Several amino acids and their derivatives have been implicated in insulin resistance (IR) and Type 2 Diabetes Mellitus (T2DM). This research sought to establish a relationship between the dietary levels of branched-chain amino acids (BCAA) and the risk of T2DM. Methods: This case-control study was carried out on 4200 participants consisting of 589 people with T2DM and 3611 non-diabetic aged 35 to 70 years residents in Sabzevar, Iran. Data on the economic-social, employment status, medical history, lifestyle, and sleep habits were collected via interview. The food frequency questionnaire (FFQ) was used to check the nutritional status. Participants’ dietary BCAA consumption was estimated using Nutritionist IV software. Results: A significant negative association between the incidence of T2DM and the dietary levels of BCAAs after adjustment for age and sex (OR = 0.972, CI 95%:0.648–0.996, P = 0.022). The negative association remained significant after additional adjustments for body mass index (BMI) and physical activity (OR = 0.967, CI 95%: 0.943–0.992, P = 0.010). Interestingly, a positive association was found between T2DM and total BCAAs (OR = 1.067, CI 95%: 1.017–1.119, P = 0.008), Isoleucine (OR = 1.248, CI 95%: 1.043–1.494, P = 0.016), Leucine (OR = 1.165, CI 95%: 1.046–1.299, P = 0.006) and Valine (OR = 1.274, CI 95%: 1.088–1.492, P = 0.003) after further adjustment for calorie intake. Conclusions: Our results demonstrate branched-chain amino acids (BCAAs) including isoleucine, leucine, and valine are negatively associated with the incidence of type 2 diabetes (T2DM) after adjusting for age and sex, BMI, and physical activity. However, adjusting for calorie intake reversed the association between T2DM and BCAAs. These findings suggest that the association between BCAAs and T2DM may be influenced by calorie intake. Future longitudinal studies are warranted. © 2023, The Author(s), under exclusive licence to Tehran University of Medical Sciences.
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