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Innovative Dual-Contrast Nanocoating for Central Venous Catheters: Prolonged Infection Resistance and Enhanced Imaging Publisher Pubmed



Golroudbari HT1 ; Mojtabavi S1 ; Mohammadi M2 ; Dehpour AR3 ; Ahmadi Tafti SH4 ; Ahmadi Tafti SM5 ; Faramarzi MA1
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  2. 2. Department of Intensive Care Unit, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Division of Colorectal Surgery, Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Materials Chemistry B Published:2025


Abstract

Central venous catheter (CVC) related bacteremia is an essential cause of hospital infections associated with morbidity, mortality, and healthcare costs. Recent advancements in catheter coatings have demonstrated an effective strategy for preventing microbial colonization and biofilm formation. In this study, CVCs coated with green and facile laccase-manganese phosphate hybrid nanostructures [(Mn3(PO4)2·HNSs] prevented bacterial adhesion by 100%, 80%, 60%, and 58% for Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli, respectively. The modified CVCs inhibited planktonic bacterial growth by up to 95% under static and dynamic flow conditions. Furthermore, the prepared CVCs showed high hemocompatibility, appropriate mechanical properties, and long-term antibacterial performance, meeting the essential requirements of catheterization. The modified catheter offered superior detectability in magnetic resonance imaging (MRI) and computed tomography (CT) scans, a valuable advancement for ongoing patient monitoring. Moreover, in vivo assessment using the mouse catheterization model revealed no inflammatory response associated with the implanted CVCs. Therefore, the prepared laccase@ Mn3(PO4)2·HNSs could be a promising strategy for developing safe and effective antibacterial coatings to combat infections associated with biomedical devices. © 2025 The Royal Society of Chemistry.