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Epstein-Barr and Bk Virus in Cancerous and Noncancerous Prostate Tissue Publisher



Malekshahi SS1 ; Yavarian J2 ; Salehi R2 ; Babaei F3 ; Ahmadi SA4 ; Ghavami N2 ; Naseri M2 ; Hosseini M5 ; Mokhtariazad T2 ; Shafieijandaghi NZ2
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Authors Affiliations
  1. 1. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2020


Abstract

Aim: We conducted a case-control study to examine the presence of BK virus (BKV) and Epstein barr virus (EBV) genome in prostate specimens of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) in Iran. Materials & methods: 64 paraffin-embedded PCa specimens were included as case subjects and 57 paraffin-embedded BPH specimens as control. DNA extraction was carried out by phenol-chloroform technique and PCR for detection of BKV and EBV. Results: 90 (73%) out of 121 specimens were collected by prostatectomy and 31 (27%) by transurethral resection of the prostate. BKV was not detected in any of the samples and one positive EBV was reported. Conclusion: These findings provide further evidence against a causative role of BKV and EBV in the development of PCa. © 2020 Future Medicine Ltd.
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