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A New Gold Nanoparticle Based Rapid Immunochromatographic Assay for Screening Ebv-Vca Specific Iga in Nasopharyngeal Carcinomas Publisher



Goudarzi S1 ; Ahmadi A2, 3 ; Farhadi M1 ; Kamrava SK1 ; Mobarrez F4 ; Omidfar K2, 3
Authors
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Authors Affiliations
  1. 1. Clinical Nanomedicine Laboratory, ENT-Head & Neck Research Center, Hazrate Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Karolinska Institutet, Department of Medicine Solna, Unit of Rheumatology, Karolinska University Hospital, Stockholm, Sweden

Source: Journal of Applied Biomedicine Published:2015


Abstract

Large screening programs of nasopharyngeal carcinoma (NPC) are still challenging due to the scarcity of the resources in higher prevalence parts of the world. In the present study, the development of a new low cost immunochromatography (ICG) strip test for screening of nasopharyngeal carcinoma is reported. A conjugate of gold nanoparticle-anti viral capsid antigen (VCA) immunoglobulin A (IgA) antibody was used as the detection probe. The test is based on a non-competitive immunoassay for rapid and reliable detection the serum specific IgA of Epstein–Barr virus (EBV) VCA. Patient serum samples were analyzed with the strip and compared with enzyme-linked immunosorbent assay (ELISA) and pathological evaluation. The obtained results from the ICG strips were well correlated with the two reference methods. An evaluation of stability, sensitivity and specificity suggested the strip suitable for NPC screening programs in high-risk peoples and also for the recurrence monitoring. © 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice
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