Characterization, Anti-Lung Cancer Activity, and Cytotoxicity of Bio-Synthesized Copper Nanoparticles by Thymus Fedtschenkoi Leaf Extract Publisher



Dehnoee A¹ ; Javad Kalbasi R¹ ; Zangeneh MM² ; Delnavazi MR³ ; Zangeneh A²
Source: Journal of Cluster Science Published:2024

Abstract

Today propose diverse techniques to remedy cancer and nanotechnology is one of the most effective cancer treatments. In this study, we detail a simple and environmentally friendly approach for synthesizing copper nanoparticles (CuNPs) using Thymus fedtschenkoi leaves extract. Studies on the structure, morphological, optical, cytotoxic, and anti-lung cancer properties of the CuNPs were conducted. The XRD pattern shows that CuNPs have a highly crystalline nature and exhibit a cubic crystal system. In order to evaluate the shape and size of the produced NPs, FE-SEM and HR-TEM were employed. The findings of the current study indicated that CuNPs had a significant growth-inhibiting effect on the lung cancer cell lines: NCI-H661, NCI-H1975, NCI-H1573, and NCI-H1563. Furthermore, the cytotoxicity effect against Human umbilical vein endothelial cells (HUVEC) was not seen at concentrations as high as 1000 μg/mL for these NPs. CuNPs are expected to be employed as a medication to treat lung cancer in upcoming clinical trials after passing the in vivo tests. Graphical Abstract: Thymus fedtschenkoi extract was employed to green synthesis of copper nanoparticles (CuNPs). CuNPs were characterized using FT-IR, TEM, XRD, SEM, DLS and UV/Vis. The anticancer, antioxidant and cytotoxicity activities of CuNPs were evaluated. The finding of biological activities showed that these CuNPs could be used as a drug to lung cancer therapy. (Figure presented.). © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.