Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial Publisher Pubmed



Aggarwal V1 ; Singla M2 ; Gupta A3 ; Kumar U4 ; Saatchi M5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Conservative Dentistry and Endodontics, Jamia Millia Islamia, Faculty of Dentistry, New Delhi, India
  2. 2. Department of Conservative Dentistry and Endodontics, SGT Dental College, Haryana, India
  3. 3. Department of Conservative Dentistry and Endodontics, Manav Rachna Dental College, Faridabad, India
  4. 4. Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Medical Sciences, Chandigarh, India
  5. 5. Department of Endodontics, Isfahan University of Medical Sciences, Faculty of Dentistry, Isfahan, Iran

Source: European Endodontic Journal Published:2024


Abstract

Objective: Tramadol hydrochloride has shown local anesthetic properties similar to lidocaine, apart from a central analgesic effect. The present study evaluated the effect of the administration of tramadol alone or in addition to 2% lidocaine, as supplementary intraligamentary injections. Methods: One hundred and five patients, with a failed primary inferior alveolar nerve block (IANB), were randomly allocated to one of the three supplementary intraligamentary groups: 2% lidocaine with 1:80,000 epinephrine; tramadol hydrochloride (50 mg/mL); and 2% lidocaine with 1:80,000 epinephrine plus tramadol hydrochloride. Patients received 1.2 mL doses (0.6 mL of each root). Patients reporting pain ≤54 on Heft Parker visual analogue scale (Heft-Parker VAS), were categorized as successful anesthesia. A finger pulse oximeter was used to measure the heart rates. The anesthetic success rates, gender, and type of tooth were compared using the Pearson chi-square test. The heart rates and age were statistically evaluated using the one-way analysis of variance test. The level of significance was set at 0.05 (p=0.05). Results: The initial IANB was successful in 31% of cases. There were significant differences in the anesthetic success rates of different supplementary intraligamentary injections (χ2= 33.6, p<0.001, df=2). The 2% lidocaine-plus-tramadol resulted in significantly higher success rates than the two groups. There were no significant changes in the baseline heart rates of all groups (p>0.05). Conclusion: The addition of tramadol to 2% lidocaine with 1:80,000 epinephrine, given as supplementary intraligamentary injection, can help in achieving successful anesthesia during the endodontic management of mandibular molars with irreversible pulpitis resistant to IANB injections. Copyright This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Related Docs
View other Related Docs
1. Effect of Cooling of Lidocaine With Epinephrine on the Anesthetic Success of Supplementary Intraligamentary Injection After a Failed Primary Inferior Alveolar Nerve Block: A Randomized Controlled Trial, European Endodontic Journal (2023)
2. Anaesthetic Efficacy of 2% Lidocaine With Different Concentrations of Epinephrine (1:80,000 and 1:200,000) in Intraligamentary Injection After a Failed Primary Inferior Alveolar Nerve Block: A Randomized Double-Blind Study, Acta Odontologica Scandinavica (2020)
3. Effect of Back-Pressure Anesthesia on Postoperative Pain After the Endodontic Treatment in Patients With Symptomatic Irreversible Pulpitis: Randomized Double-Blind Clinical Trial, Journal of Endodontics (2024)
4. Effect of Magnesium Sulphate Added to Lidocaine on Inferior Alveolar Nerve Block Success in Patients With Symptoms of Irreversible Pulpitis: A Prospective, Randomized Clinical Trial, International Endodontic Journal (2020)
5. Effect of Fentanyl on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial, Giornale Italiano di Endodonzia (2022)
6. Preoperative Intraligamentary Injection of Dexamethasone Can Improve the Anesthetic Success Rate of 2% Lidocaine During the Endodontic Management of Mandibular Molars With Symptomatic Irreversible Pulpitis, Journal of Endodontics (2021)
7. Anesthetic Efficacy of Gow-Gates Nerve Block, Inferior Alveolar Nerve Block, and Their Combination in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Clinical Trial, Journal of Endodontics (2018)
8. Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block In Mandibular First Molars With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-Blind Study, Journal of Endodontics (2016)
Experts (# of related papers)
View all Related Experts
Azim Honarmand (28)
Mohammad Reza Safavi (23)
Other Related Docs
9. Preincisional Analgesia With Subcutaneous Administration of Tramadol Reduces Postoperative Pain in Patients After Open Urologic Surgeries: A Randomized, Double-Blind, Placebo-Controlled Study, Pakistan Journal of Medical Sciences (2012)
10. Effect of Sodium Bicarbonate-Buffered Lidocaine on the Success of Inferior Alveolar Nerve Block for Teeth With Symptomatic Irreversible Pulpitis: A Prospective, Randomized Double-Blind Study, Journal of Endodontics (2015)
11. Anaesthetic Efficacy of Lidocaine/Clonidine for Inferior Alveolar Nerve Block in Patients With Irreversible Pulpitis, International Endodontic Journal (2017)
12. Effectiveness of Local Anesthesia With Lidocaine in Chronic Opium Abusers, Journal of Emergencies, Trauma and Shock (2014)
13. Effect of Chlordiazepoxide and Oxazepam on the Success Rate of Mandibular Nerve Block Anesthesia: A Randomized Double Blind Control Trial, Advances in Environmental Biology (2014)
14. The Effect of Adding Metoclopramide to Subcutaneous Lidocaine on Postoperative Pain After Lower Abdominal Surgery With General Anesthesia, Journal of Isfahan Medical School (2011)
15. Evaluation of Prophylactic Injection of Two Doses of Tramadol on Heart Rate and Blood Pressure Changes Compared With Control Group After Laryngoscopy and Intubation, Journal of Isfahan Medical School (2016)
16. Comparison of Continuous Infusions of Ketorolac, Paracetamol and Parecoxib for Postoperative Pain Management in Orthopedic Lower Limb Surgery Undergoing Spinal Anesthesia, Journal of Cellular and Molecular Anesthesia (2019)
17. Comparison of Effect of Intravenous Ketamine, Peritonsillar Infiltration of Tramadol and Their Combination on Pediatric Posttonsillectomy Pain: A Double-Blinded Randomized Placebo-Controlled Clinical Trial, Research in Pharmaceutical Sciences (2013)
18. The Effect of Intravenous Morphine on the Level of Spinal Anesthesia With Lidocaine., Medicinski arhiv (2012)
19. Effect of Preoperative Alprazolam on the Success of Inferior Alveolar Nerve Block for Teeth With Irreversible Pulpitis, Journal of Endodontics (2012)
20. Effect of Different Methods of Skin Infiltration of Local Anesthetics on Pain During Spinal Anesthesia Induction, Journal of Isfahan Medical School (2013)
21. Minimum Effective Dose of Tramadol in the Treatment of Postanesthetic Shivering, Journal of Research in Medical Sciences (2008)
22. Effects of Intravenous Ketamine and Tramadol on the Amount of Antiemetics Used in General Anesthetic Patients, Journal of Isfahan Medical School (2012)
23. Preventive Effect of Different Doses of Tramadol on Postoperative Shivering During and After Lower Limb Orthopedic Surgery Under Spinal Anesthesia As Compared to Control Group, Journal of Isfahan Medical School (2018)
24. Anesthetic Efficacy of Lidocaine/Ketorolac in Inferior Alveolar Nerve Block in Patients With Irreversible Pulpitis: A Randomized Clinical Trial, European endodontic journal (2020)
25. The Comparison of Spinal Anesthesia With General Anesthesia on the Postoperative Pain Scores and Analgesic Requirements After Elective Lower Abdominal Surgery: A Randomized, Double-Blinded Study, Journal of Research in Medical Sciences (2013)
26. Effects of Lidocaine on Reducing the Need for Anesthetic Drugs During Ophthalmologic Surgeries, Journal of Isfahan Medical School (2013)
27. Tramadol Versus Meperidine in the Treatment of Shivering During Spinal Anesthesia in Cesarean Section, Journal of Research in Medical Sciences (2006)
28. Injection of Lidocaine Alone Versus Lidocaine Plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evaluation, Pain Research and Management (2021)
29. Comparing the Hemodynamic Effects of Nebulized Dexmedetomidine and Nebulized Lidocaine in Children Undergoing Fiberoptic Bronchoscopy, Journal of Advances in Medical and Biomedical Research (2019)
30. Comparative Evaluation of Bispectral Index System After Sedation With Midazolam and Propofol Combined With Remifentanil Versus Ketamine in Uncooperative During Dental Procedures, Dental Research Journal (2016)
31. Effects of Adding Two Different Doses of Intrathecal Magnesium Sulfate to Bupivacaine in Laminectomy Surgeries Under Spinal Anesthesia, Journal of Isfahan Medical School (2017)
32. The Effect of Early Ambulation on the Incidence of Neurological Complication After Spinal Anesthesia With Lidocaine, Journal of Research in Medical Sciences (2015)
33. A Comparative Study of the Effect of Adding Dexmedetomidine, Dexamethasone and Sodium Bicarbonate to Ropivacaine in Ultrasound Guided Supraclavicular Block on the Quality of the Block in Orthopedic Surgery, Archives of Anesthesiology and Critical Care (2024)
34. Ketamine/Propofol Versus Midazolam/Fentanyl for Procedural Sedation and Analgesia in the Emergency Department: A Randomized, Prospective, Double-Blind Trial, Academic Emergency Medicine (2011)
35. Comparing the Effects of Ketamine Alone and in Combination With Metoclopramide on Postoperative Pain, Journal of Isfahan Medical School (2013)
36. Comparing the Effect of Lidocaine-Prilocaine Cream and Infiltrative Lidocaine on Overall Pain Perception During Thoracentesis and Abdominocentesis: A Randomized Clinical Trial, Anesthesiology and Pain Medicine (2020)
37. Comparison of the Effect of Hematoma Block and Injection of Lidocaine With and Without Ketamine on Reduction of Pain in Patients With Distal Radius Fracture, Journal of Isfahan Medical School (2021)
38. Comparison of Low-Dose Naloxone With Ondansetron for Prevention of Sufentanil-Postoperative/Postdischarge Nausea and Vomiting, Archives of Anesthesiology and Critical Care (2024)
39. Postoperative Analgesia After Caesarean Section: Intermittent Intramuscular Versus Subcutaneous Morphine Boluses, Acute Pain (2007)
40. Effect of Different Doses of Paracetamol on Postoperative Pain After Gynecologic Laparoscopy, International Journal of Women's Health and Reproduction Sciences (2018)
41. Comparison of the Efficacy of Methadone and Tramadol in Opioid-Assisted Detoxification, Iranian Journal of Medical Sciences (2007)
42. Mini-Dose Bier's Block Vs Systemic Analgesia in Distal Radius Fractures: A Promising Reduction in Emergency Department Throughput Time, Pain Management (2023)
43. Comparison of the Effects of 3 Methods of Intrathecal Bupivacaine, Bupivacaine-Fentanyl, and Bupivacaine-Fentanyl-Magnesium Sulfate on Sensory Motor Blocks and Postoperative Pain in Patients Undergoing Lumbar Disk Herniation Surgery, Journal of Neurosurgical Anesthesiology (2016)
44. Supplementing Epidural Lidocaine With Midazolam: Effect on Sensorymotor Block Level, Acta Anaesthesiologica Taiwanica (2004)
45. Comparison of the Effect of Intravenous Fentanyl With Low-Dose Ketamine on Pain Relief in Patients Taking Methadone and Suffering From Limb Fractures, Advanced Biomedical Research (2023)
46. Effect of Low-Dose Ketamine Versus Lidocaine on Hemodynamic Response to Endotracheal Intubation in General Anesthesia: A Prospective, Triple-Blinded, Randomized Controlled Trial, Tehran University Medical Journal (2023)
47. Evaluation of the Distribution of Topical Bupivacaine in Epidural Anesthesia With Mri, Journal of Isfahan Medical School (2011)
48. Comparison of Success Rate and Onset Time of Two Different Anesthesia Techniques, Medicina Oral, Patologia Oral y Cirugia Bucal (2015)
49. The Efficacy Comparison of Ibuprofen, Acetaminophen-Codeine, and Placebo Premedication Therapy on the Depth of Anesthesia During Treatment of Inflamed Teeth, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology (2006)
50. Comparison Between the Effect of Bupivacaine-Pethidine and Bupivacaine-Ketamine As Preemptive in Bilateral Infraorbital Nerve Block on Postoperative Pain Relief in Infants Undergoing Clef Lip Repair, a Controlled Study, Journal of Isfahan Medical School (2017)