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Simultaneous Spectrophotometric Determination of Amlodipine and Metoprolol by Principal Component Regression Multivariate Calibration and Comparison With Hplc



Shahlaei M1 ; Hassanzadeh F2 ; Emami J3 ; Sohrabi E2 ; Saghaie L2
Authors

Source: Journal of Reports in Pharmaceutical Sciences Published:2013

Abstract

Multi-drug therapy in high blood pressure is appreciated to achieve a normal blood pressure. A simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (Amd) and metoprolol (Met) in pharmaceutical preparations. Calibration matrix contains 3.402 μgml-1 to 170.130 μg ml-1 amlodipine and 13.7 μg ml-1 to 68.5 μgml-1 metoprolol. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of amlodipine and metoprolol in different pharmaceutical preparations. © 2012 by Kermanshah University of Medical Sciences.