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Rit2 Polymorphisms: Is There a Differential Association? Publisher Pubmed



Emamalizadeh B1 ; Jamshidi J2 ; Movafagh A1 ; Ohadi M3 ; Khaniani MS4, 5 ; Kazeminasab S6 ; Biglarian A7 ; Taghavi S1 ; Motallebi M1 ; Fazeli A1 ; Ahmadifard A1 ; Shahidi GA8 ; Petramfar P9 ; Shahmohammadibeni N10 Show All Authors
Authors
  1. Emamalizadeh B1
  2. Jamshidi J2
  3. Movafagh A1
  4. Ohadi M3
  5. Khaniani MS4, 5
  6. Kazeminasab S6
  7. Biglarian A7
  8. Taghavi S1
  9. Motallebi M1
  10. Fazeli A1
  11. Ahmadifard A1
  12. Shahidi GA8
  13. Petramfar P9
  14. Shahmohammadibeni N10
  15. Dadkhah T10
  16. Khademi E10
  17. Tafakhori A11
  18. Khaligh A12
  19. Safaralizadeh T1
  20. Kowsari A13
  21. Mirabzadeh A14
  22. Zarneh AES1
  23. Khorrami M15
  24. Shokraeian P16
  25. Banavandi MJS17
  26. Lima BS18
  27. Andarva M1
  28. Alehabib E1
  29. Atakhorrami M1
  30. Darvish H1
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, Faculty of Medicine, Tabriz University of medical Sciences, Tabriz, Iran
  5. 5. Neurosciences Research Center, Tabriz University of medical Sciences, Tabriz, Iran
  6. 6. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  7. 7. Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  8. 8. Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
  11. 11. Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Sabzevar University of Medical Sciences, Sabzevar, Iran
  13. 13. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  14. 14. Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  15. 15. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  16. 16. Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  17. 17. Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
  18. 18. Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Molecular Neurobiology Published:2017


Abstract

Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson’s disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders. © 2016, Springer Science+Business Media New York.