Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress Publisher Pubmed

Summary: Study links MIC-1/GDF15 and VEGF to obesity and lipid levels, suggesting prognostic roles. What’s their role in metabolism? #Obesity #MetabolicHealth

Parvaneh RR1 ; Vajdi M2 ; Shiraz AN3 ; Khani M4 ; Farshbaf SE4 ; Farhangi MA5
Authors

Source: Nutrition and Health Published:2023


Abstract

Background: Macrophage inhibitory cytokine 1-Growth differentiation Factor 15 (MIC-1/GDF15) and vascular endothelial growth factor (VEGF) are novel regulators of obesity and energy homeostasis and food intake. Aims: In the current cross-sectional study, we aimed to evaluate MIC-1 and VEGF concentrations and their association with serum lipids and biomarkers of oxidative stress in obese individuals. Methods: Fifty six obese subjects, aged between 20–50 years old, participated in the current study. Anthropometric and nutritional parameters were assessed and serum and blood concentrations of MIC-1/GDF15, VEGF, markers of oxidative stress and serum lipids were evaluated. Results: Serum VEGF was strongly associated with serum lipids and MIC-1/GDF15 concentrations while serum MIC-1/GDF15 was associated with total cholesterol (TC) and VEGF levels. In multivariate regression analysis, serum VEGF, appetite and GPX were potent determinants of MIC-1/GDF15 concentrations while VEGF was only associated with serum MIC-1/GDF15. Conclusion: The findings of the current study demonstrated the association between MIC-1/GDF15 and VEGF. Moreover, a positive association between these cytokines and serum lipids, was also observed. The results suggest that MIC-1/GDF15 and VEGF might be considered as prognostic markers in obesity-related metabolic disorders. Although further mechanistic studies are needed to better clarify the underlying mechanism. © The Author(s) 2022.
Related Docs
View other Related Docs
1. Effects of Dapt on Serum Vascular Endothelial Growth Factor and Its Soluble Receptor in Obese Balb/C Mice, Journal of Isfahan Medical School (2013)
2. Macronutrients and Postprandial Inflammation in the Metabolic Syndrome: Review of Current Evidence, Journal of Isfahan Medical School (2012)
3. The Effects of Vitamin E and Omega-3 Pufas on Endothelial Function Among Adolescents With Metabolic Syndrome, BioMed Research International (2014)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (2)
Noushin Mohammadifard (2)
Prognostic Value of Circulating Macrophage Inhibitory Cytokine 1-Growth Differentiation Factor 15 (Mic-1/Gdf15) in Obesity: Relation With Vascular Endothelial Growth Factor (Vegf) and Markers of Oxidative Stress
Other Related Docs
4. Comparative Effects of Carbohydrate Versus Fat Restriction on Serum Levels of Adipocytokines, Markers of Inflammation, and Endothelial Function Among Women With the Metabolic Syndrome: A Randomized Cross-Over Clinical Trial, Annals of Nutrition and Metabolism (2013)
5. Efficacy of Orlistat for the Treatment of Metabolic Dysfunction–Associated Steatotic Liver Disease Patients: A Systematic Review and Meta-Analysis, Hepatology Forum (2025)
6. Does Lipoic Acid Consumption Affect the Cytokine Profile in Multiple Sclerosis Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial, NeuroImmunoModulation (2014)
7. Dietary Intakes of Monounsaturated Fatty Acids and Risk of Mortality From All Causes, Cardiovascular Disease and Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Ageing Research Reviews (2021)
8. Associations Between Dietary Insulin Load With Cardiovascular Risk Factors and Inflammatory Parameters in Elderly Men: A Cross-Sectional Study, British Journal of Nutrition (2019)
9. Dairy Consumption and Circulating Levels of Inflammatory Markers Among Iranian Women, Public Health Nutrition (2010)
10. The Effect of Low Calorie Diet on Adiponectin Concentration: A Systematic Review and Meta-Analysis, Hormone and Metabolic Research (2015)
11. The Relationship Between Inflammatory Markers, Angiogenesis, and Obesity, ARYA Atherosclerosis (2013)
12. Angiopoietin-Like Proteins 2 and 3 in Children and Adolescents With Obesity and Their Relationship With Hypertension and Metabolic Syndrome, International Journal of Hypertension (2021)
13. Association of Polyunsaturated Fatty Acid Intake on Inflammatory Gene Expression and Multiple Sclerosis: A Systematic Review and Meta-Analysis, Nutrients (2022)
14. Magnesium Intake, Insulin Resistance and Markers of Endothelial Function Among Women, Public Health Nutrition (2021)
15. Body Mass Index, Waist-Circumference and Cardiovascular Disease Risk Factors in Iranian Adults: Isfahan Healthy Heart Program, Journal of Health, Population and Nutrition (2013)
16. Association of Changes in Oxidative and Proinflammatory States With Changes in Vascular Function After a Lifestyle Modification Trial Among Obese Children, Clinical Chemistry (2008)
17. Association Between Serum Cytokine Concentrations and the Presence of Hypertriglyceridemia, Clinical Biochemistry (2016)
18. Correlation of Serum Pro-Inflammatory (Il 6) and Anti-Inflammatory (Il 10) Interleukine Levels With Fatty Acid Composition of Dietary Oils in Rats, Scientific Journal of Kurdistan University of Medical Sciences (2013)
19. Lipid Accumulation Product and Visceral Adiposity Index for Incidence of Cardiovascular Diseases and Mortality; Results From 13 Years Follow-Up in Isfahan Cohort Study, Obesity Science and Practice (2024)
20. Suppressive Impact of Anethum Graveolens Consumption on Biochemical Risk Factors of Atherosclerosis in Hypercholesterolemic Rabbits, International Journal of Preventive Medicine (2013)