Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Sumac (Rhus Coriaria L.) Powder Supplementation in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial Publisher Pubmed



Kazemi S1 ; Shidfar F1 ; Ehsani S1 ; Adibi P2 ; Janani L3 ; Eslami O1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Source: Complementary Therapies in Clinical Practice Published:2020


Abstract

Background: In recent years, great attention has been paid to the role of herbal medicine in the management of non-alcoholic fatty liver disease (NAFLD). Sumac (Rhus coriaria L.) is a popular herb which contains major bioactive compounds known for a variety of health benefits. This study aimed to assess the effects of sumac powder supplementation on hepatic fibrosis and some metabolic markers in patients with NAFLD. Methods: Eighty-four patients diagnosed with NAFLD were included in this randomized double-blind placebo-controlled clinical trial. They were randomly assigned to receive 2000 mg per day sumac powder (n = 42) or placebo (n = 42) for 12 weeks. Also, both groups received a 500-calories deficit diet plan. Hepatic fibrosis and liver enzymes (ALT and AST) as well as fasting blood sugar (FBS), serum insulin, HbA1c, HOMA-IR (insulin resistance index), QUICKI (insulin sensitivity index), malondialdehyde (MDA), and high sensitivity C-reactive protein (hs-CRP) were measured at baseline and the end of trial. Results: Eighty patients completed the trial. After 12-weeks of intervention, subjects in the sumac group showed a greater decrease in hepatic fibrosis and liver enzymes as well as FBS, serum insulin, HbA1c, HOMA-IR, MDA, and hs-CRP, compared to the placebo (P-value < 0.05); while the QUICKI was significantly higher in the sumac group at the end of intervention. Conclusion: Daily intake of 2000 mg sumac powder along with a low-calorie diet for 12 weeks was beneficial for the management of NAFLD. © 2020 Elsevier Ltd
Related Docs
View other Related Docs
1. Effects of Sumac Supplementation on Metabolic Markers in Adults With Metabolic Syndrome: A Triple-Blinded Randomized Placebo-Controlled Cross-Over Clinical Trial, Nutrition Journal (2023)
2. The Effect of Sumac Supplementation on Insulin Resistance, Inflammation, Oxidative Stress, and Antioxidant Capacity in Adults With Metabolic Syndrome: A Randomized Crossover Clinical Trial, Phytotherapy Research (2023)
3. The Effect of Sumac on Cardiovascular Risk Factors in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Prostaglandins and Other Lipid Mediators (2024)
4. The Effect of Curcumin Pill in Treatment of Non-Alcoholic Fatty Liver Disease: A Clinical Trial Study, Journal of Isfahan Medical School (2017)
5. Effect of a Moderately Carbohydrate-Restricted Diet on Liver Enzymes, Steatosis and Fibrosis in Normal-Weight Individuals With Non-Alcoholic Fatty Liver Disease: Study Protocol for a Parallel Randomised Controlled Clinical Trial, BMJ Open (2023)
6. Effect of Sumac Powder Supplementation on Anthropometric Indices: A Systematic Review and Meta-Analysis of Randomised Controlled Trials, Journal of Herbal Medicine (2023)
7. Potential Cardioprotective Effects of Sumac Capsule in Patients With Hyperlipidemia: A Triple-Blind Randomized, Placebo-Controlled Crossover Trial, Journal of the American College of Nutrition (2018)
8. Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women With Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial, International journal of clinical practice (2022)
Experts (# of related papers)
View all Related Experts
Gholamreza Askari (21)
Awat Feizi (11)
Other Related Docs
9. Effects of a Novel Therapeutic Diet on Liver Enzymes and Coagulating Factors in Patients With Non-Alcoholic Fatty Liver Disease: A Parallel Randomized Trial, Nutrition (2014)
10. Effects of a Low-Calorie, Low-Carbohydrate Soy Containing Diet on Systemic Inflammation Among Patients With Nonalcoholic Fatty Liver Disease: A Parallel Randomized Clinical Trial, Hormone and Metabolic Research (2017)
11. The Efficacy of Vitamin D Supplementation Against Nonalcoholic Fatty Liver Disease: A Meta-Analysis, Journal of Dietary Supplements (2020)
12. Effect of Green Coffee Bean Extract Supplementation on Liver Function and Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Clinical Practice (2021)
13. Efficacy of Synbiotic Supplementation in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials: Synbiotic Supplementation and Nafld, Critical Reviews in Food Science and Nutrition (2019)
14. Adherence to Low Carbohydrate Diets and Non-Alcoholic Fatty Liver Disease: A Case Control Study, BMC Nutrition (2022)
15. Effect of Pioglitazone on Nonalcoholic Fatty Liver Disease in Morbid Obese Patients; a Randomized Controlled Trial, Advanced Biomedical Research (2023)
16. The Effect of Silymarin on Non-Alcoholic Fatty Liver Disease of Children, Journal of HerbMed Pharmacology (2017)
17. The Effects of Low Carbohydrate Diets on Liver Function Tests in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Clinical Trials, Journal of Research in Medical Sciences (2016)
18. The Effect of Symbiotic Supplementation on Liver Enzymes, C‑Reactive Protein and Ultrasound Findings in Patients With Non‑Alcoholic Fatty Liver Disease: A Clinical Trial, International Journal of Preventive Medicine (2016)
19. Effect of Vitamin D Supplementation on C-Reactive Protein in Patients With Nonalcoholic Fatty Liver, International Journal of Preventive Medicine (2014)
20. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Preventive Medicine (2015)
21. The Association Between Major Dietary Patterns With the Risk of Non-Alcoholic Fatty Liver Disease, Oxidative Stress and Metabolic Parameters: A Case–Control Study, Journal of Diabetes and Metabolic Disorders (2022)
22. The Effect of Vitamin D Supplementation on Blood Sugar and Different Indices of Insulin Resistance in Patients With Non-Alcoholic Fatty Liver Disease (Nafld), Iranian Journal of Nursing and Midwifery Research (2016)
23. The Effect of Synbiotic Supplementation on Body Composition and Lipid Profile in Patients With Nafld: A Randomized, Double Blind, Placebo-Controlled Clinical Trial Study, Iranian Red Crescent Medical Journal (2017)
24. Treatment of Non-Alcoholic Fatty Liver Disease With Curcumin: A Randomized Placebo-Controlled Trial, Phytotherapy Research (2016)
25. Effects of the Mixture of Melissa Officinalis L., Cinnamomum Zeylanicutn and Urtica Dioica on Hepatic Enzymes Activity in Patients With Nonalcoholic Fatty Liver Disease, International Journal of Pharmacology (2012)
26. The Effect of a Mediterranean Diet on Metabolic Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
27. The Association of Dietary Phytochemical Index and Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
28. Diet Macronutrients Composition in Nonalcoholic Fatty Liver Disease: A Review on the Related Documents, Hepatitis Monthly (2014)
29. Clinical Effects of Rhus Coriaria Fruits on Dyslipidemia308 in Adolescents: A Triple-Blinded Randomized Placebo-Controlled Trial, Medical archives (Sarajevo, Bosnia and Herzegovina) (2014)
30. The Effects of Curcumin Supplementation on Liver Function, Metabolic Profile and Body Composition in Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
31. Effect of Sour Tea Supplementation on Liver Enzymes, Lipid Profile, Blood Pressure, and Antioxidant Status in Patients With Non-Alcoholic Fatty Liver Disease: A Double-Blind Randomized Controlled Clinical Trial, Phytotherapy Research (2021)
32. Effect of Vitamin D Supplement on Nonalcoholic Fatty Liver: A Systematic Review on Randomized Clinical Trials, Journal of Health System Research (2020)
33. No Benefit of Soluble Fiber on Liver Function: A Systematic Review and Meta-Analysis of Controlled Trials, International Journal for Vitamin and Nutrition Research (2024)
34. Sustained Feeding of a Diet High in Fat Resulted in a Decline in the Liver's Insulin-Degrading Enzyme Levels in Association With the Induction of Oxidative and Endoplasmic Reticulum Stress in Adult Male Rats: Evaluation of 4-Phenylbutyric Acid, Heliyon (2024)
35. Dietary Quality Indices and Biochemical Parameters Among Patients With Non Alcoholic Fatty Liver Disease (Nafld), Hepatitis Monthly (2013)
36. A Comprehensive Insight Into the Effect of Berberine on Nonalcoholic Fatty Liver Disease (Nafld): A Systematic Review, Journal of Food Biochemistry (2023)
37. The Effects of Ursodeoxycholic Acid on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMC Cardiovascular Disorders (2025)
38. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
39. The Effect of Zinc Supplementation on Steatosis Severity and Liver Function Enzymes in Overweight/Obese Patients With Mild to Moderate Non-Alcoholic Fatty Liver Following Calorie-Restricted Diet: A Double-Blind, Randomized Placebo-Controlled Trial, Biological Trace Element Research (2020)
40. Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat, Iranian Biomedical Journal (2003)
41. Can Flaxseed Supplementation Affect Circulating Adipokines in Adults? an Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Nutrition (2023)
42. Efficacy of Curcumin Plus Piperine Co-Supplementation in Moderate-To-High Hepatic Steatosis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Phytotherapy Research (2023)
43. The Effect of Curcumin on Anthropometric Indices, Blood Pressure, Lipid Profiles, Fasting Blood Glucose, Liver Enzymes, Fibrosis, and Steatosis in Non-Alcoholic Fatty Livers, Frontiers in Nutrition (2023)
44. Dietary Phytochemical Index and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study Among Iranian Adults, Complementary Therapies in Medicine (2022)
45. Evaluation of the Effect of Hydroalcoholic Extract of Dracocephalum Kotschyi Boiss on Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats; [اثر عصارهی هیدروالکلی زرین گیاه بر فیبروز کبدی ناشی از تتراکلرید کربن در رتهای نر بالغ], Journal of Isfahan Medical School (2022)
46. Hepatic Artery and Portal Vein Doppler Indexes in Non-Alcoholic Fatty Liver Disease Before and After Treatment to Prevent Unnecessary Health Care Costs, International Journal of Preventive Medicine (2014)
47. The Effect of Psyllium on Anthropometric Measurements and Liver Enzymes in Overweight or Obese Adults With Nonalcoholic Fatty Liver Disease (Nafld), Journal of Isfahan Medical School (2015)
48. The Effect of Vitamin D Supplementation on Insulin Resistance in Patients With Nonalcoholic Fatty Liver, Journal of Isfahan Medical School (2015)
49. The Effect of Sesame Oil Consumption Compared to Sunflower Oil on Lipid Profile, Blood Pressure, and Anthropometric Indices in Women With Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blind Controlled Trial, Trials (2022)
50. The Effects of Realsil (Silybin–Phospholipid–Vitamin E Complex) on Liver Enzymes in Patients With Non-Alcoholic Fatty Liver Disease (Nafld) or Nonalcoholic Steato-Hepatitis (Nash): A Systematic Review and Meta-Analysis of Rcts, Acta Endocrinologica (2020)