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Effects of Angiotensin Ii and Captopril on Rewarding Propreties of Morphine Pubmed



Hosseini M1 ; Sharifi MR2 ; Alaei H2 ; Shafei MN1 ; Karimooy HAN1
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Indian Journal of Experimental Biology Published:2007


Abstract

The effects of captopril and Ang II on morphine-induced conditioned place preference (CPP) and morphine selfadministration in male Wistar rat were investigated. In CPP experiment, injection of captopril before test significantly decreased the difference of the time spent in compartment A between pre- and post-conditioning compared to morphine group. In self- administration experiment number of active lever pressing was significantly greater than passive in morphine group. In captopril group number of active lever pressing was significantly lower than morphine group however, there was not significant difference between active and passive lever pressed number. The results showed that captopril significantly decreased morphine-induced conditional place preference and morphine self-administration but the effect of Ang II was not significant. It can be concluded that RAS may have a role in rewarding properties of morphine.
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