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Detection of Colistin Sensitivity in Clinical Isolates of Acinetobacter Baumannii in Iran



Vakili B1 ; Fazeli H2 ; Shoaei P3 ; Yaran M4 ; Ataei B2 ; Khorvash F3 ; Khaleghi M5
Authors
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Authors Affiliations
  1. 1. Departments of Microbiology, Science and Research Branch, Islami Azad University, Kerman, Iran
  2. 2. Infectious Diseases and Tropical Medicine Research Center, Isfahan, Iran
  3. 3. Nosocomial Infection Research Center, Isfahan, Iran
  4. 4. Acquired Immunodefi ciency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biology, Shahid Bahonar University of Kerman, Iran

Source: Journal of Research in Medical Sciences Published:2014

Abstract

Background: Nosocomial infection caused by Acinetobacter baumannii has emerged as a serious problem world-wide. Finding the suitable drug is an important priority. The aim of this study was to determine colistin (polymyxin E) resistance in clinical isolates of A. baumannii from intensive care units (ICUs) of Al Zahra Hospital. Materials and Methods: Sixty isolates of A. baumannii from patients hospitalized in ICU (Al Zahra Hospital, Isfahan University of Medical Sciences [IUMS]) were studied. All isolates of A. baumannii were tested for colistin susceptibility by Eopsilometer test (E-test). Results: Of the 60 isolates 57, (95%) were multidrug resistant (MDR) and 76.6% (46/60) were highly resistant. The rate of colistin resistant with the E-test method was 11.6% (7/60). Conclusion: As the frequency of resistance to colistin is low, it can be used as an easily available drug for treatment of MDR A. baumannii strains, which are susceptible to colistin.
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