Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparing the Hemodynamic Effects of Nitroglycerin and Labetalol Infusion for Hypertension and Heart Rate Control Before and During Induction to Cardiopulmonary Arrest in Patients Under Coronary Artery Bypass Graft



Masoumi G1 ; Toloueghamari M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Anesthesiology and Critical Care. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2016

Abstract

Background: This study was aimed to compare the hemodynamic effects of nitroglycerin and labetalol infusion for hypertension and heart rate control in the before and during induction to cardiopulmonary arrest in patients under coronary artery bypass graft. Methods: In a clinical trial study, 70 candidates for coronary bypass were selected and randomly divided in the two groups. In the first group nitroglycerin and in the second group labetalol was injected and hemodynamic changes, blood gas levels, incidence of arythmia during and after surgery was measured. Also amount of anti-arythmic drugs, inotrop, pack cell and DC shock need were studied and compared between the two groups. Findings: Incidence of cardiac arrhythmia in the nitroglycerin and labetalol was 9 and 5 (25.7% VS 3.14%) (P = 0.370), also need to anti-arrhythmic drugs in the two groups was 22.9% and 2.9%, respectively (P = 0.028). Conclusion: Using labetalol in patients under coronary artery bypass graft is better than nitroglycerin for hemodynamic and blood gases. Also, incidence of cardiac arrhythmia during cardiopulmonary arrest is lower and labetalol is preferred to nitroglycerin and recommended according to surgeons and anesthesiologists. © 2016, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Effect of Different Dosages of Nitroglycerin Infusion on Arterial Blood Gas Tensions in Patients Undergoing On- Pump Coronary Artery Bypass Graft Surgery, Journal of Research in Medical Sciences (2012)
2. The Effect of Intravenous Injection of Amiodarone on Central Venous Pressure in Patients Undergoing Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2018)
3. The Effects of Mean Arterial Pressure During Cardiopulmonary Bypass on Clinical and Paraclinical Parameters During and After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2012)
4. Effect of Low-Dose Dopamine on Lactate Level in Patients Undergoing Coronary Bypass Surgery, Iranian Heart Journal (2013)
5. Comparative Study of Clinical Outcomes of Methylprednisolone and Dexamethasone in Prime Solution During Cardiopulmonary Pump After Coronary Artery Bypass Grafting, Journal of Cellular and Molecular Anesthesia (2021)
6. Comparing the Hemodynamic Changes During and After Coronary Artery Bypass Graft Surgery Under General Anesthesia With Propofol and Isoflurane, Journal of Isfahan Medical School (2015)
7. Evaluating Hemodynamic Outcomes of Different Dosages of Intravenous Nitroglycerin After Coronary Artery Bypass Graft Surgery, Journal of Research in Medical Sciences (2011)
8. Evaluation of Vasodilatory Effect of Nitroglycerin in Cardioplegia Solution on Patients Undergoing Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2023)
Experts (# of related papers)
View all Related Experts
Gholamreza Massoumi (11)
Mojtaba Mansouri (9)
Other Related Docs
9. The Effect of Labetalol or Remifentanil on Blood Pressure and Heart Rate After Laryngoscopy and Intubation, Journal of Isfahan Medical School (2017)
10. Treatment of Intraoperative Sinus Tachycardia With Neostigmine Methylsulfate, Life Science Journal (2012)
11. The Comparison of the Effects of Fentanyl and Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Stereotactic Surgery, Journal of Isfahan Medical School (2022)
12. Comparison of Blood Electrolytes and Glucose During Cardiopulmonary Bypass in Diabetic and Non-Diabetic Patients, Journal of Research in Medical Sciences (2013)
13. Comparison of the Effect of 1:1 and 1:2 Frequencies of Intra-Aortic Balloon Pump on Hemodynamics of the Patients Undergoing Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2022)
14. Comparative Study of the Effect of Two Different Doses of Intravenous Labetalol on the Cardiovascular Response to Endotracheal Extubation, Journal of Cardiovascular and Thoracic Research (2023)
15. A Comparison of the Clinical Outcomes of Minimum and Maximum Hematocrit Levels During Cardiopulmonary Bypass (Cpb) in Low‑Risk Patients Undergoing Coronary Artery Bypass Graft Surgery (Cabg): A Cross‑Sectional Study, Advanced Biomedical Research (2024)
16. The Effect of Incentive Spirometry on Arterial Blood Gases After Coronary Artery Bypass Surgery (Cabg), Iranian Journal of Nursing and Midwifery Research (2016)
17. Comparing the Effects of Pantoprazole and Ranitidine in the Prevention of Post-Operative Gastrointestinal Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2016)
18. The Effect of Intracoronary Versus Intralesional Injection of Eptifibatide on Myocardial Perfusion Outcomes During Primary Percutaneous Coronary Intervention in Acute St-Segment Elevation Myocardial Infarction; a Randomized Clinical Trial Study, ARYA Atherosclerosis (2019)
19. Comparative Evaluation of the Effects of Different Doses of Labetalol on Cardiovascular Response to Tracheal Intubation, Journal of Isfahan Medical School (2016)
20. The Effect of Zolpidem or Promethazine Premedication on Agitation, Sedation and Cognitive Disorders Before and After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2015)
21. Evaluation of the Effect of Modafinil on Respiratory and Cerebral Outcomes After Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2021)
22. Efficacy of Epsilon Aminocaproic Acid Versus Placebo in Coronary Artery Bypass Graft: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Treatment Options in Cardiovascular Medicine (2024)
23. Comparison of the Incidence and Severity of Delirium and Biochemical Factors After Coronary Artery Bypass Grafting With Dexmedetomidine: A Randomized Double-Blind Placebo-Controlled Clinical Trial Study, ARYA Atherosclerosis (2019)
24. Comparison of Survival Rate and Complications of Percutaneous Coronary Intervention, Coronary Artery Bypass Graft, and Medical Treatment in Patients With Left Main And/Or Three Vessel Diseases, ARYA Atherosclerosis (2020)
25. Nifedipine, Captopril or Sublingual Nitroglycerin, Which Can Reduce Blood Pressure the Most?, ARYA Atherosclerosis (2011)
26. Perioperative Myocardial Infarction Diagnosis After Coronary Artery Bypass Grafting Surgery Using Coupled Electrocardiographic Changes and Cardiac Troponin I, Indian Journal of Thoracic and Cardiovascular Surgery (2019)
27. The Effects of Trinitroglycerin Injection on Early Complications of Angiography, ARYA Atherosclerosis (2012)
28. Cotimparave Evaluation of Oral Alprazolam, As Premedication, on Controlling Blood Pressure in Hypertensive Patients During Surgery, Journal of Isfahan Medical School (2015)
29. Obstructive Sleep Apnea and Postoperative Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Need for Preventive Strategies, International Journal of Preventive Medicine (2014)
30. Cardiopulmonary Arrest After Cardiac Surgery: A Retrospective Cohort of 142 Patients With Nine Year Follow Up, Heart and Lung (2021)
31. Evaluation of the Effects of Two Different Doses of Midodrine Alpha-Agonist on Prevention of Vasoplegia Caused by Cardiopulmonary Bypass Pump, Journal of Isfahan Medical School (2017)
32. The Effect of N-Acetylcysteine in Prime Solution on Reducing Damage to the Myocardium in Open Heart Surgery, Journal of Isfahan Medical School (2024)
33. Possible Effects of Melatonin on Reperfusion Injury Following Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2022)
34. Evaluating the Effect of Mebudipine on Hemodynamical Parameters and Histological Changes in Isolated Heart Induced by Ischemic-Reperfusion Injury in Male Rat, Pharmaceutical Sciences (2009)
35. Effect of Vasopressin on Electrocardiographic Changes Produced by Ischemia-Reperfusion in Rats, Pakistan Journal of Pharmaceutical Sciences (2021)
36. The Effect of Dexmedetomidine Infusion Vs. Morphine on Duration of Mechanical Ventilation in Cabg: A Clinical Trial, Journal of Cellular and Molecular Anesthesia (2021)
37. The Association Between Serum Lactate Level and Post Cabg Complications in Cardiac Patients, Journal of Isfahan Medical School (2011)
38. Early Chest Tube Removal After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2010)
39. Postoperative Cardiac Arrest in Children With Congenital Heart Abnormalities, ARYA Atherosclerosis (2013)
40. Evaluation of the Preventive Effect of Midodrine Administration on Vasoplegia During Cardiac Surgery, Compared With the Control Group, Journal of Isfahan Medical School (2016)
41. Comparison of Two Modes of Ventilation After Fast-Track Cardiac Surgery: Adaptive Support Ventilation Versus Synchronized Intermittent Mandatory Ventilation, Pakistan Journal of Medical Sciences (2012)
42. Effects of Single Antegrade Hot Shot in Comparison With No Hot Shot Administration During Coronary Artery Bypass Grafting, ARYA Atherosclerosis (2015)
43. Preconditioning by Isoflurane As a Volatile Anesthetic in Elective Coronary Artery Bypass Surgery, ARYA Atherosclerosis (2013)
44. The Effect of Metoprolol During Rewarming on the Incidence of Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting, Journal of Isfahan Medical School (2021)
45. Determination the Efficacy of Clonidine Premedication on Intraoperative Cardiovascular Stability and Frequency Distribution of Cardiac Complication With Placebo After Non Cardiac Surgery, Journal of Isfahan Medical School (2008)
46. The Effect of Combined Conventional and Modified Ultrafiltration on Mechanical Ventilation and Hemodynamic Changes in Congenital Heart Surgery, Journal of Research in Medical Sciences (2016)
47. The Comparison of the Effect of Handmade Del Nido and St. Thomas Cardioplegia Solutions on Quantitative Levels of Troponin I and Creatine Kinase-Myocardial Band (Cpk-Mb) in Repair of Pediatric Ventricular Septal Defect, Journal of Isfahan Medical School (2020)
48. Comparative Evaluation of Changes of Cardiac Output and Stroke Volume Due to the Increase of Tidal Volume in Mechanical Ventilation of Pulmonary During Controlled Hypotension by Nitroglycerine and Na Nitroprusside, Journal of Babol University of Medical Sciences (2014)
49. The Relation Between the Mean Time Interval of Opening of Aortic Cross Clamp to the End of Cardiopulmonary Bypass With Surgical Results of Patient After Coronary Artery Bypass Grafting Surgery, Journal of Isfahan Medical School (2017)
50. Detrimental Predictive Effect of Metabolic Syndrome on Postoperative Complications in Patients Who Undergoing Coronary Artery Bypass Grafting, Acta Biomedica (2015)